caa a22 4500 605492875 CHVBK 20210128100517.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00261-014-0342-3 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0342-3 A case of β-catenin-positive hepatocellular adenoma with MR imaging sign of diffuse intratumoral fat deposition [Elektronische Daten] [Masaya Ishii, Junichi Kazaoka, Junichi Fukushima, Mariko Gunji, Toru Aoyama, Toshio Fukusato, Keiji Sano, Fukuo Kondo, Toru Takeshita, Shigeru Furui, Masaaki Akahane] Hepatocellular adenoma (HCA) is a rare primary benign tumor of the liver, which occurs predominantly in young and middle-aged women. Recently, the subclassification of HCA was proposed by the Bordeaux group. Subsequently, characteristic radiological and clinical features have been revealed in each HCA subtype. According to the previous literature, diffuse intratumoral fat deposition is a very common finding in hepatocyte nuclear factor 1α-negative HCA, but this finding has been reported in β-catenin-positive HCA in the literature for only one case. In this case report, we report the second case of β-catenin-positive HCA with MR imaging sign of diffuse intratumoral fat deposition, confirmed immunohistologically on the basis of a surgical specimen. In addition, our case showed hypovascularity and isointensity on the hepatobiliary phase which have been reported as characteristic findings in β-catenin-positive HCA. Diffuse intratumoral fat deposition can be observed in β-catenin-positive HCA, which has a greater probability of malignant transformation than other types of HCA. Springer Science+Business Media New York, 2015 β-Catenin-positive hepatocellular adenoma nationallicence Hepatocellular adenoma nationallicence Diffuse intratumoral fat deposition nationallicence Diffuse intratumoral steatosis nationallicence Ishii Masaya Department of Radiology, NTT Medical Center Tokyo, 5-9-22 Higashigotanda, 141-0022, Shinagawa-ku, Tokyo, Japan aut Kazaoka Junichi Department of Radiology, NTT Medical Center Tokyo, 5-9-22 Higashigotanda, 141-0022, Shinagawa-ku, Tokyo, Japan aut Fukushima Junichi Department of Pathology, Gyoda General Hospital, 376 Mochida, 361-0056, Gyoda-shi, Saitama, Japan aut Gunji Mariko Department of Diagnostic Pathology, NTT Medical Center Tokyo, 5-9-22 Higashigotanda, 141-0022, Shinagawa-ku, Tokyo, Japan aut Aoyama Toru Division of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, 350-8550, Kawagoe-shi, Saitama, Japan aut Fukusato Toshio Department of Pathology, Teikyo University School of Medicine, 2-11-1 Kaga, 173-8606, Itabashi-ku, Tokyo, Japan aut Sano Keiji Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, 173-8606, Itabashi-ku, Tokyo, Japan aut Kondo Fukuo Department of Pathology, Teikyo University School of Medicine, 2-11-1 Kaga, 173-8606, Itabashi-ku, Tokyo, Japan aut Takeshita Toru Department of Radiology, Teikyo University School of Medicine, 2-11-1 Kaga, 173-8606, Itabashi-ku, Tokyo, Japan aut Furui Shigeru Department of Radiology, Teikyo University School of Medicine, 2-11-1 Kaga, 173-8606, Itabashi-ku, Tokyo, Japan aut Akahane Masaaki Department of Radiology, NTT Medical Center Tokyo, 5-9-22 Higashigotanda, 141-0022, Shinagawa-ku, Tokyo, Japan aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1487-1491 0942-8925 40:6<1487 2015 40 261 https://doi.org/10.1007/s00261-014-0342-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0342-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ishii Masaya Department of Radiology, NTT Medical Center Tokyo, 5-9-22 Higashigotanda, 141-0022, Shinagawa-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Kazaoka Junichi Department of Radiology, NTT Medical Center Tokyo, 5-9-22 Higashigotanda, 141-0022, Shinagawa-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Fukushima Junichi Department of Pathology, Gyoda General Hospital, 376 Mochida, 361-0056, Gyoda-shi, Saitama, Japan aut NATIONALLICENCE 700 1- Gunji Mariko Department of Diagnostic Pathology, NTT Medical Center Tokyo, 5-9-22 Higashigotanda, 141-0022, Shinagawa-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Aoyama Toru Division of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, 350-8550, Kawagoe-shi, Saitama, Japan aut NATIONALLICENCE 700 1- Fukusato Toshio Department of Pathology, Teikyo University School of Medicine, 2-11-1 Kaga, 173-8606, Itabashi-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Sano Keiji Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, 173-8606, Itabashi-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Kondo Fukuo Department of Pathology, Teikyo University School of Medicine, 2-11-1 Kaga, 173-8606, Itabashi-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Takeshita Toru Department of Radiology, Teikyo University School of Medicine, 2-11-1 Kaga, 173-8606, Itabashi-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Furui Shigeru Department of Radiology, Teikyo University School of Medicine, 2-11-1 Kaga, 173-8606, Itabashi-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Akahane Masaaki Department of Radiology, NTT Medical Center Tokyo, 5-9-22 Higashigotanda, 141-0022, Shinagawa-ku, Tokyo, Japan aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1487-1491 0942-8925 40:6<1487 2015 40 261