18F-FDG PET/CT as a potential predictor of survival in patient with oesophageal cancer: a preliminary result
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| 024 | 7 | 0 | |a 10.1007/s00261-014-0343-2 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-014-0343-2 | ||
| 245 | 0 | 0 | |a 18F-FDG PET/CT as a potential predictor of survival in patient with oesophageal cancer: a preliminary result |h [Elektronische Daten] |c [A. Fathinul Fikri, R. Dharmendran, P. Vikneswaran, A. Nordin] |
| 520 | 3 | |a Aims: A study was undertaken to investigate the value of pretreatment PET-CT in predicting survival in patients with oesophageal cancer (OC). Methods: Between June 2010 and December 2011, 18 consecutive OC patients median (61.00±12.07years) with median survival of 7.5 month had a pretreatment PET-CT scan. Staging of the disease was made in accordance to the American Joint Committee on Cancer staging system (7th edition) and grouped as stage I-IIA and stage IIB-IV. Maximum standardized uptake value (SUVmax), size of a primary tumour and the presence of fluorodeoxyglucose (FDG)-avid lymph nodes were evaluated for all patients. Survival was analysed using the Kaplan-Meier product limit method and Cox proportional hazards regression model. Results: PET-CT stages I-IIA and IIB-IV had a 1-year survival of 50% and 25%, respectively. Patient with size of primary tumour (<4.5cm) had significantly (p<0.036) better survival than those with large size (>4.5cm). Multivariate Cox regression analysis showed that SUVmax of >5.5 in the primary tumour [hazard ratio (HR) 23.017; 95% confidence interval, p=0.038] and the presence of FDG-avid lymph node (HR 1.248; p=0.028) were strongly predictive of poor overall survival on multivariate analysis. Conclusion: Pretreatment 18F-FDG PET-CT SUVmax of a primary tumour and the presence of FDG-avid lymph nodes independently predict survival in patients with oesophageal carcinoma which may potentially be used as surrogate markers for prognostic and therapeutic purposes. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Oesophageal carcinoma |2 nationallicence | |
| 690 | 7 | |a FDG PET |2 nationallicence | |
| 690 | 7 | |a PE-CT |2 nationallicence | |
| 690 | 7 | |a Survival |2 nationallicence | |
| 690 | 7 | |a SUVmax |2 nationallicence | |
| 700 | 1 | |a Fathinul Fikri |D A. |u Centre for Diagnostic Nuclear Imaging, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia |4 aut | |
| 700 | 1 | |a Dharmendran |D R. |u Department of Surgery, Hospital Tuanku Ja'afar, 70300, Seremban, Negeri Sembilan, Malaysia |4 aut | |
| 700 | 1 | |a Vikneswaran |D P. |u Department of Surgery, Hospital Tuanku Ja'afar, 70300, Seremban, Negeri Sembilan, Malaysia |4 aut | |
| 700 | 1 | |a Nordin |D A. |u Centre for Diagnostic Nuclear Imaging, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/6(2015-08-01), 1457-1464 |x 0942-8925 |q 40:6<1457 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-014-0343-2 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-014-0343-2 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fathinul Fikri |D A. |u Centre for Diagnostic Nuclear Imaging, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dharmendran |D R. |u Department of Surgery, Hospital Tuanku Ja'afar, 70300, Seremban, Negeri Sembilan, Malaysia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Vikneswaran |D P. |u Department of Surgery, Hospital Tuanku Ja'afar, 70300, Seremban, Negeri Sembilan, Malaysia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nordin |D A. |u Centre for Diagnostic Nuclear Imaging, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/6(2015-08-01), 1457-1464 |x 0942-8925 |q 40:6<1457 |1 2015 |2 40 |o 261 | ||