caa a22 4500 605492891 CHVBK 20210128100518.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00261-014-0343-2 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0343-2 18F-FDG PET/CT as a potential predictor of survival in patient with oesophageal cancer: a preliminary result [Elektronische Daten] [A. Fathinul Fikri, R. Dharmendran, P. Vikneswaran, A. Nordin] Aims: A study was undertaken to investigate the value of pretreatment PET-CT in predicting survival in patients with oesophageal cancer (OC). Methods: Between June 2010 and December 2011, 18 consecutive OC patients median (61.00±12.07years) with median survival of 7.5 month had a pretreatment PET-CT scan. Staging of the disease was made in accordance to the American Joint Committee on Cancer staging system (7th edition) and grouped as stage I-IIA and stage IIB-IV. Maximum standardized uptake value (SUVmax), size of a primary tumour and the presence of fluorodeoxyglucose (FDG)-avid lymph nodes were evaluated for all patients. Survival was analysed using the Kaplan-Meier product limit method and Cox proportional hazards regression model. Results: PET-CT stages I-IIA and IIB-IV had a 1-year survival of 50% and 25%, respectively. Patient with size of primary tumour (<4.5cm) had significantly (p<0.036) better survival than those with large size (>4.5cm). Multivariate Cox regression analysis showed that SUVmax of >5.5 in the primary tumour [hazard ratio (HR) 23.017; 95% confidence interval, p=0.038] and the presence of FDG-avid lymph node (HR 1.248; p=0.028) were strongly predictive of poor overall survival on multivariate analysis. Conclusion: Pretreatment 18F-FDG PET-CT SUVmax of a primary tumour and the presence of FDG-avid lymph nodes independently predict survival in patients with oesophageal carcinoma which may potentially be used as surrogate markers for prognostic and therapeutic purposes. Springer Science+Business Media New York, 2015 Oesophageal carcinoma nationallicence FDG PET nationallicence PE-CT nationallicence Survival nationallicence SUVmax nationallicence Fathinul Fikri A. Centre for Diagnostic Nuclear Imaging, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia aut Dharmendran R. Department of Surgery, Hospital Tuanku Ja'afar, 70300, Seremban, Negeri Sembilan, Malaysia aut Vikneswaran P. Department of Surgery, Hospital Tuanku Ja'afar, 70300, Seremban, Negeri Sembilan, Malaysia aut Nordin A. Centre for Diagnostic Nuclear Imaging, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1457-1464 0942-8925 40:6<1457 2015 40 261 https://doi.org/10.1007/s00261-014-0343-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0343-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fathinul Fikri A. Centre for Diagnostic Nuclear Imaging, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia aut NATIONALLICENCE 700 1- Dharmendran R. Department of Surgery, Hospital Tuanku Ja'afar, 70300, Seremban, Negeri Sembilan, Malaysia aut NATIONALLICENCE 700 1- Vikneswaran P. Department of Surgery, Hospital Tuanku Ja'afar, 70300, Seremban, Negeri Sembilan, Malaysia aut NATIONALLICENCE 700 1- Nordin A. Centre for Diagnostic Nuclear Imaging, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1457-1464 0942-8925 40:6<1457 2015 40 261