MR-PET evaluation of 1-month post-ablation therapy for hepatocellular carcinoma: preliminary observations
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| 024 | 7 | 0 | |a 10.1007/s00261-015-0436-6 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-015-0436-6 | ||
| 245 | 0 | 0 | |a MR-PET evaluation of 1-month post-ablation therapy for hepatocellular carcinoma: preliminary observations |h [Elektronische Daten] |c [Miguel Ramalho, Mamdoh AlObaidy, Lauren Burke, Brian Dale, David Gerber, Terence Wong, Richard Semelka] |
| 520 | 3 | |a Purpose: The purpose of the study was to evaluate the feasibility and protocol optimization of whole-body hybrid MR-PET system performed 1-month after post-locoregional thermoablative procedures for hepatocellular carcinomas (HCCs). Materials and methods: Eight patients (6 men and 2 women; mean age, 56.6±5.5years) with 9 ablated HCCs constituted our study population. Three readers interpreted the studies to determine the presence or absence of residual malignancy. Two readers independently assessed the fused MR-PET images to compare registration accuracy of two types of T2-weighted (triggered T2 half-Fourier acquisition single-shot turbo spin-echo and turbo spin-echo) and T1-weighted [Cartesian and radial 3D gradient echo (GRE)]. Image quality evaluation of both 3D-GRE T1-weighted sequences was evaluated. Kappa statistics were used to measure inter-observer agreement. Non-parametric Kruskal-Wallis and Wilcoxon signed-rank tests were used for qualitative data analysis. Results: Definite residual tumor was observed in 3/9 ablations; two were PET positive. All residual tumors were isovascular on MRI. Radial 3D-GRE demonstrated significantly superior MR-PET subjective co-registration in comparison with the remaining sequences and showed a non-significant trend toward higher image quality scores than Cartesian GRE. Conclusion: Whole-body hybrid MR-PET is feasible as a part of 1-month follow-up post-locoregional thermoablative treatment for HCC. Radial 3D-GRE offers improved co-registration with PET data, with overall good image quality. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Hepatocellular carcinoma |2 nationallicence | |
| 690 | 7 | |a Whole-body hybrid MR-PET |2 nationallicence | |
| 690 | 7 | |a Thermoablation |2 nationallicence | |
| 690 | 7 | |a Residual disease |2 nationallicence | |
| 690 | 7 | |a FDG |2 nationallicence | |
| 700 | 1 | |a Ramalho |D Miguel |u Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA |4 aut | |
| 700 | 1 | |a AlObaidy |D Mamdoh |u Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA |4 aut | |
| 700 | 1 | |a Burke |D Lauren |u Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA |4 aut | |
| 700 | 1 | |a Dale |D Brian |u Siemens Medical Solution, 27599-7510, Cary, NC, USA |4 aut | |
| 700 | 1 | |a Gerber |D David |u Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA |4 aut | |
| 700 | 1 | |a Wong |D Terence |u Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA |4 aut | |
| 700 | 1 | |a Semelka |D Richard |u Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/6(2015-08-01), 1405-1414 |x 0942-8925 |q 40:6<1405 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-015-0436-6 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-015-0436-6 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ramalho |D Miguel |u Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a AlObaidy |D Mamdoh |u Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Burke |D Lauren |u Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dale |D Brian |u Siemens Medical Solution, 27599-7510, Cary, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gerber |D David |u Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wong |D Terence |u Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Semelka |D Richard |u Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/6(2015-08-01), 1405-1414 |x 0942-8925 |q 40:6<1405 |1 2015 |2 40 |o 261 | ||