caa a22 4500 605492999 CHVBK 20210128100518.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00261-015-0436-6 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0436-6 MR-PET evaluation of 1-month post-ablation therapy for hepatocellular carcinoma: preliminary observations [Elektronische Daten] [Miguel Ramalho, Mamdoh AlObaidy, Lauren Burke, Brian Dale, David Gerber, Terence Wong, Richard Semelka] Purpose: The purpose of the study was to evaluate the feasibility and protocol optimization of whole-body hybrid MR-PET system performed 1-month after post-locoregional thermoablative procedures for hepatocellular carcinomas (HCCs). Materials and methods: Eight patients (6 men and 2 women; mean age, 56.6±5.5years) with 9 ablated HCCs constituted our study population. Three readers interpreted the studies to determine the presence or absence of residual malignancy. Two readers independently assessed the fused MR-PET images to compare registration accuracy of two types of T2-weighted (triggered T2 half-Fourier acquisition single-shot turbo spin-echo and turbo spin-echo) and T1-weighted [Cartesian and radial 3D gradient echo (GRE)]. Image quality evaluation of both 3D-GRE T1-weighted sequences was evaluated. Kappa statistics were used to measure inter-observer agreement. Non-parametric Kruskal-Wallis and Wilcoxon signed-rank tests were used for qualitative data analysis. Results: Definite residual tumor was observed in 3/9 ablations; two were PET positive. All residual tumors were isovascular on MRI. Radial 3D-GRE demonstrated significantly superior MR-PET subjective co-registration in comparison with the remaining sequences and showed a non-significant trend toward higher image quality scores than Cartesian GRE. Conclusion: Whole-body hybrid MR-PET is feasible as a part of 1-month follow-up post-locoregional thermoablative treatment for HCC. Radial 3D-GRE offers improved co-registration with PET data, with overall good image quality. Springer Science+Business Media New York, 2015 Hepatocellular carcinoma nationallicence Whole-body hybrid MR-PET nationallicence Thermoablation nationallicence Residual disease nationallicence FDG nationallicence Ramalho Miguel Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA aut AlObaidy Mamdoh Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA aut Burke Lauren Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA aut Dale Brian Siemens Medical Solution, 27599-7510, Cary, NC, USA aut Gerber David Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA aut Wong Terence Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA aut Semelka Richard Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1405-1414 0942-8925 40:6<1405 2015 40 261 https://doi.org/10.1007/s00261-015-0436-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0436-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ramalho Miguel Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- AlObaidy Mamdoh Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Burke Lauren Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Dale Brian Siemens Medical Solution, 27599-7510, Cary, NC, USA aut NATIONALLICENCE 700 1- Gerber David Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Wong Terence Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Semelka Richard Department of Radiology, University Of North Carolina at Chapel Hill, 2001 Old Clinic Bldg., CB 7510, 7599-7510, Chapel Hill, NC, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/6(2015-08-01), 1405-1414 0942-8925 40:6<1405 2015 40 261