Biphenotypic hepatic tumors: imaging findings and review of literature
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| 005 | 20210128100518.0 | ||
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| 008 | 210128e20151001xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00261-015-0433-9 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-015-0433-9 | ||
| 245 | 0 | 0 | |a Biphenotypic hepatic tumors: imaging findings and review of literature |h [Elektronische Daten] |c [Michael Wells, Sudhakar Venkatesh, Vishal Chandan, Jeff Fidler, Joel Fletcher, Geoffrey Johnson, David Hough, Lewis Roberts] |
| 520 | 3 | |a Purpose: To describe imaging findings in biphenotypic hepatic tumors (BPT) and a proposal for new imaging classification based on contrast-enhanced imaging. Methods: Retrospective review of CT, MRI, PET/CT, and ultrasound findings in 39 patients with histologically confirmed BPT was performed. Tumor markers including AFP, L3 fraction, CA 19.9, CA 125, and CEA were recorded. Based on the dynamic enhancement features, BPT were categorized into 4 enhancement patterns (Types 1-4). Enhancement patterns were correlated with other imaging findings and tumor markers. Imaging features and tumor markers that were not consistent with diagnosis of hepatocellular carcinoma or intrahepatic cholangiocarcinoma based on enhancement pattern were considered discordant findings. Results: Enhancement patterns in 29 patients (CT/MR) included 23 Type 2 (continuous peripheral rim of late arterial hyperenhancement with washout or fade in portal venous and/or delayed phases, ±delayed central enhancement) and 2 of each Types 1, 2, and 3. Discordant imaging findings were present in two patients with Type 2 pattern and in one patient with Type 1 pattern. Both AFP and CA 19.9 were elevated in 15 of 33 of patients. Tumor markers AFP and CA 19.9 were discordant in 17 of 21 patients with Type 2 pattern, two of two patients with Type 3 pattern. Most BPTs were markedly PET avid with average SUV max of 8.2. Most frequent ultrasound appearance is peripheral hypoechogenicity and central hyperechogenicity. Conclusions: BPT most commonly present with imaging features similar to cholangiocarcinoma or metastases. BPT can be suggested when imaging findings or tumor markers are discordant with the most likely diagnosis based on enhancement pattern. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Biphenotypic hepatic tumor |2 nationallicence | |
| 690 | 7 | |a Computed tomography (CT) |2 nationallicence | |
| 690 | 7 | |a Magnetic resonance imaging (MRI) |2 nationallicence | |
| 690 | 7 | |a Ultrasound (US) |2 nationallicence | |
| 690 | 7 | |a Positron emission tomography (PET) |2 nationallicence | |
| 700 | 1 | |a Wells |D Michael |u Department of Radiology, College of Medicine, Mayo Clinic, 200 First St. SW, 55905, Rochester, MN, USA |4 aut | |
| 700 | 1 | |a Venkatesh |D Sudhakar |u Department of Radiology, College of Medicine, Mayo Clinic, 200 First St. SW, 55905, Rochester, MN, USA |4 aut | |
| 700 | 1 | |a Chandan |D Vishal |u Department of Pathology, Mayo Clinic, Rochester, MN, USA |4 aut | |
| 700 | 1 | |a Fidler |D Jeff |u Department of Radiology, College of Medicine, Mayo Clinic, 200 First St. SW, 55905, Rochester, MN, USA |4 aut | |
| 700 | 1 | |a Fletcher |D Joel |u Department of Radiology, College of Medicine, Mayo Clinic, 200 First St. SW, 55905, Rochester, MN, USA |4 aut | |
| 700 | 1 | |a Johnson |D Geoffrey |u Department of Radiology, College of Medicine, Mayo Clinic, 200 First St. SW, 55905, Rochester, MN, USA |4 aut | |
| 700 | 1 | |a Hough |D David |u Department of Radiology, College of Medicine, Mayo Clinic, 200 First St. SW, 55905, Rochester, MN, USA |4 aut | |
| 700 | 1 | |a Roberts |D Lewis |u Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/7(2015-10-01), 2293-2305 |x 0942-8925 |q 40:7<2293 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-015-0433-9 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-015-0433-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wells |D Michael |u Department of Radiology, College of Medicine, Mayo Clinic, 200 First St. SW, 55905, Rochester, MN, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Venkatesh |D Sudhakar |u Department of Radiology, College of Medicine, Mayo Clinic, 200 First St. SW, 55905, Rochester, MN, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chandan |D Vishal |u Department of Pathology, Mayo Clinic, Rochester, MN, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fidler |D Jeff |u Department of Radiology, College of Medicine, Mayo Clinic, 200 First St. SW, 55905, Rochester, MN, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fletcher |D Joel |u Department of Radiology, College of Medicine, Mayo Clinic, 200 First St. SW, 55905, Rochester, MN, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Johnson |D Geoffrey |u Department of Radiology, College of Medicine, Mayo Clinic, 200 First St. SW, 55905, Rochester, MN, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hough |D David |u Department of Radiology, College of Medicine, Mayo Clinic, 200 First St. SW, 55905, Rochester, MN, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Roberts |D Lewis |u Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/7(2015-10-01), 2293-2305 |x 0942-8925 |q 40:7<2293 |1 2015 |2 40 |o 261 | ||