caa a22 4500 605493057 CHVBK 20210128100518.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0461-5 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0461-5 MR imaging of spleen in beta-thalassemia major [Elektronische Daten] [Olympia Papakonstantinou, Eleni Drakonaki, Tomas Maris, Artemis Vasiliadou, Alex Papadakis, Nicholas Gourtsoyiannis] Purpose: Splenomegaly and splenic siderosis are well-known findings in beta-thalassemia major. We explored the relation between splenic size, splenic and hepatic siderosis in transfusion-dependent beta-thalassemic patients, assessed by MR imaging. Materials and methods: Abdominal MR imaging studies of 47 consecutive thalassemic patients and 10 healthy subjects, used as controls, were retrospectively reviewed. The signal intensity ratios of spleen and liver to the right paraspinous muscle (S/M, L/M, respectively) were calculated on T1, intermediate, and T2*-weighted gradient-echo sequences, splenic volume was estimated on axial images and serum ferritin levels were recorded. Results: Decreased S/M on all MR sequences was displayed in 36 patients. Six patients presented with normal S/M on all MR sequences and 5 patients displayed splenic hypointensity only on T2* sequence. No correlation between S/M and L/M was found whereas both L/M and S/M correlated with serum ferritin (P<0.03). Splenic volume correlated to L/M (P<0.05) but not to S/M values. Conclusion: In transfusion-dependent patients with beta-thalassemia, iron deposition in spleen cannot be predicted by the degree of hepatic siderosis, whereas splenomegaly relates to liver, but not splenic, iron overload. MR imaging can be a valuable tool in elucidating iron kinetics. Springer Science+Business Media New York, 2015 Thalassemia nationallicence MR imaging nationallicence Iron nationallicence Spleen nationallicence Liver nationallicence Papakonstantinou Olympia 2nd Department of Radiology, Attikon Hospital, 12464, Athens, Greece aut Drakonaki Eleni Department of Radiology, University of Crete, Heraklion, Crete, Greece aut Maris Tomas Department of Radiology, University of Crete, Heraklion, Crete, Greece aut Vasiliadou Artemis Thalassemia Unit, "Aghios Georgios” Hospital of Chania, Chania, Crete, Greece aut Papadakis Alex Thalassemia Unit, "Venizelion” Hospital of Heraklion, Heraklion, Crete, Greece aut Gourtsoyiannis Nicholas Department of Radiology, University of Crete, Heraklion, Crete, Greece aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2777-2782 0942-8925 40:7<2777 2015 40 261 https://doi.org/10.1007/s00261-015-0461-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0461-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Papakonstantinou Olympia 2nd Department of Radiology, Attikon Hospital, 12464, Athens, Greece aut NATIONALLICENCE 700 1- Drakonaki Eleni Department of Radiology, University of Crete, Heraklion, Crete, Greece aut NATIONALLICENCE 700 1- Maris Tomas Department of Radiology, University of Crete, Heraklion, Crete, Greece aut NATIONALLICENCE 700 1- Vasiliadou Artemis Thalassemia Unit, "Aghios Georgios” Hospital of Chania, Chania, Crete, Greece aut NATIONALLICENCE 700 1- Papadakis Alex Thalassemia Unit, "Venizelion” Hospital of Heraklion, Heraklion, Crete, Greece aut NATIONALLICENCE 700 1- Gourtsoyiannis Nicholas Department of Radiology, University of Crete, Heraklion, Crete, Greece aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2777-2782 0942-8925 40:7<2777 2015 40 261