caa a22 4500 605493138 CHVBK 20210128100519.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0488-7 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0488-7 The target sign in colorectal liver metastases: an atypical Gd-EOB-DTPA "uptake” on the hepatobiliary phase of MR imaging [Elektronische Daten] [Vincenza Granata, Orlando Catalano, Roberta Fusco, Fabiana Tatangelo, Daniela Rega, Guglielmo Nasti, Antonio Avallone, Mauro Piccirillo, Francesco Izzo, Antonella Petrillo] Purpose: To describe the MRI findings in colorectal cancer liver metastases using gadoxetic acid (Gd-EOB-DTPA), with special emphasis on the target feature seen on the hepatobiliary phase. Material and methods: The medical records of 45 colorectal cancer patients with an overall number of 150 liver metastases were reviewed. All patients underwent Gd-EOB-DTPA-enhanced MRI before any kind of treatment. We retrospectively evaluated, for each lesion, the signal intensity on the T1-weighted, T2-weighted, and diffusion-weighted images. Additionally, the enhancement pattern during the arterial-, portal-, equilibrium-, and hepatobiliary-phase was assessed. Fourteen lesions had a pathological correlation. Results: Lesions size was 5-40 mm (mean 15 mm). All metastases were hypointense on T1-w imaging. Ninety-nine lesions (66%) had a central area of very high signal intensity on T2-w imaging. Fifty-one metastases (34%) were hyperintense on the T2-w images. In DWI, all lesions had a restricted diffusion. The mean ADC value was 1.31×10−3mm2/s (range 1.10-1.45×10−3mm2/s). During the arterial-phase imaging, 61 lesions (41%) showed a rim enhancement, while 89 lesions (59%) appeared as hypointense. All lesions had low signal intensity in the portal and equilibrium phase. Thirty-nine percent of the lesions also showed an enhancing rim on the portal-phase images. During the hepatobiliary phase, 80 lesions (53.3%) were hypointense, while 70 lesions (46.7%) had a target appearance. Conclusion: A number of metastases show an atypical contrast medium uptake during the hepatobiliary phase of gadoxetic acid-enhanced MRI, consisting in a target appearance. Springer Science+Business Media New York, 2015 Colorectal cancer nationallicence Liver metastasis nationallicence Magnetic resonance imaging nationallicence Gadoxetic acid nationallicence Granata Vincenza First Department of Radiology, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut Catalano Orlando First Department of Radiology, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut Fusco Roberta First Department of Radiology, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut Tatangelo Fabiana Department of Pathology, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut Rega Daniela Department of Colorectal Surgical Oncology, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut Nasti Guglielmo Department of Colorectal Medical Oncology, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut Avallone Antonio Department of Abdominal Medical Oncology, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut Piccirillo Mauro Department of Hepatobiliary Surgery, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut Izzo Francesco Department of Hepatobiliary Surgery, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut Petrillo Antonella First Department of Radiology, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2364-2371 0942-8925 40:7<2364 2015 40 261 https://doi.org/10.1007/s00261-015-0488-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0488-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Granata Vincenza First Department of Radiology, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Catalano Orlando First Department of Radiology, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Fusco Roberta First Department of Radiology, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Tatangelo Fabiana Department of Pathology, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Rega Daniela Department of Colorectal Surgical Oncology, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Nasti Guglielmo Department of Colorectal Medical Oncology, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Avallone Antonio Department of Abdominal Medical Oncology, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Piccirillo Mauro Department of Hepatobiliary Surgery, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Izzo Francesco Department of Hepatobiliary Surgery, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Petrillo Antonella First Department of Radiology, Istituto Nazionale Tumori Fondazione G.Pascale, via Mariano Semmola, 80131, Naples, Italy aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2364-2371 0942-8925 40:7<2364 2015 40 261