Use of vessel patterns on contrast-enhanced ultrasonography using a perflubutane-based contrast agent for the differential diagnosis of regenerative nodules from early hepatocellular carcinoma or high-grade dysplastic nodules in patients with chronic liver disease
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 605493170 | ||
| 003 | CHVBK | ||
| 005 | 20210128100519.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20151001xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00261-015-0489-6 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-015-0489-6 | ||
| 245 | 0 | 0 | |a Use of vessel patterns on contrast-enhanced ultrasonography using a perflubutane-based contrast agent for the differential diagnosis of regenerative nodules from early hepatocellular carcinoma or high-grade dysplastic nodules in patients with chronic liver disease |h [Elektronische Daten] |c [Kazushi Numata, Hiroyuki Fukuda, Hiromi Nihonmatsu, Masaaki Kondo, Akito Nozaki, Makoto Chuma, Manabu Morimoto, Takashi Oshima, Masahiro Okada, Takamichi Murakami, Shigeo Takebayashi, Shin Maeda, Yoshiaki Inayama, Masayuki Nakano, Katsuaki Tanaka] |
| 520 | 3 | |a Objective: We evaluated the use of tumor vessel patterns observed during arterial-phase contrast-enhanced ultrasonography (US) to differentiate regenerative nodules (RN) from early hepatocellular carcinoma (HCC) or high-grade dysplastic nodules (HGDN) in patients with chronic liver disease. Subjects and methods: Pathologically confirmed lesions (83 early HCC, 6 HGDN, and 13 RN with mean maximal diameters of 15.4, 15.3, and 16.2mm, respectively) were enrolled in this retrospective study. We performed contrast-enhanced US using a perflubutane-based contrast agent. We then classified the tumor vessels observed during the arterial phase of contrast-enhanced US into two patterns: peripheral vessels (centripetal pattern) and central vessels (centrifugal pattern). Results: Eighty-one (97.6%) of the 83 early HCC exhibited various enhancement patterns (hypovascular, 44.6%; isovascular, 25.3%; and hypervascular, 27.7%) and a peripheral vessel pattern, while the remaining 2 lesions (2.4%) exhibited hypovascular enhancement and a central vessel pattern. All 6 HGDN lesions were hypovascular with a peripheral vessel pattern. Twelve (92.3%) of the 13 RN were hypovascular with a central vessel pattern, and the remaining one (7.7%) was hypervascular with a central vessel pattern. When lesions exhibiting a central vessel pattern during arterial-phase contrast-enhanced US were diagnosed as RN, the sensitivity, specificity, and accuracy of these diagnoses were 100%, 97.8%, and 98.0%, respectively. Conclusion: The tumor vessel patterns observed during arterial-phase contrast-enhanced US may be useful for differentiating RN from early HCC or HGDN in patients with chronic liver disease. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Contrast-enhanced ultrasonography |2 nationallicence | |
| 690 | 7 | |a Early hepatocellular carcinoma |2 nationallicence | |
| 690 | 7 | |a Regenerative nodule |2 nationallicence | |
| 690 | 7 | |a High-grade dysplastic nodule |2 nationallicence | |
| 690 | 7 | |a Tumor vessel |2 nationallicence | |
| 700 | 1 | |a Numata |D Kazushi |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Fukuda |D Hiroyuki |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Nihonmatsu |D Hiromi |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Kondo |D Masaaki |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Nozaki |D Akito |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Chuma |D Makoto |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Morimoto |D Manabu |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Oshima |D Takashi |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Okada |D Masahiro |u Department of Radiology, University Hospital of the Ryukyus, 207 Azakamihara, Nishihara-cho, 903-0215, Nakagami-gun, Okinawa, Japan |4 aut | |
| 700 | 1 | |a Murakami |D Takamichi |u Department of Radiology, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi, 589-8511, Osaka-Sayama, Osaka, Japan |4 aut | |
| 700 | 1 | |a Takebayashi |D Shigeo |u Department of Radiology, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Maeda |D Shin |u Division of Gastroenterology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Inayama |D Yoshiaki |u Department of Pathology, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Nakano |D Masayuki |u Pathological Department, Shonan Fujisawa Tokusyukai Hospital, 1-5-1 Kamidai, Tusjido, 251-0041, Fujisawa, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Tanaka |D Katsuaki |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/7(2015-10-01), 2372-2383 |x 0942-8925 |q 40:7<2372 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-015-0489-6 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-015-0489-6 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Numata |D Kazushi |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fukuda |D Hiroyuki |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nihonmatsu |D Hiromi |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kondo |D Masaaki |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nozaki |D Akito |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chuma |D Makoto |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Morimoto |D Manabu |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Oshima |D Takashi |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Okada |D Masahiro |u Department of Radiology, University Hospital of the Ryukyus, 207 Azakamihara, Nishihara-cho, 903-0215, Nakagami-gun, Okinawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Murakami |D Takamichi |u Department of Radiology, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi, 589-8511, Osaka-Sayama, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Takebayashi |D Shigeo |u Department of Radiology, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Maeda |D Shin |u Division of Gastroenterology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Inayama |D Yoshiaki |u Department of Pathology, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nakano |D Masayuki |u Pathological Department, Shonan Fujisawa Tokusyukai Hospital, 1-5-1 Kamidai, Tusjido, 251-0041, Fujisawa, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tanaka |D Katsuaki |u Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/7(2015-10-01), 2372-2383 |x 0942-8925 |q 40:7<2372 |1 2015 |2 40 |o 261 | ||