caa a22 4500 605493170 CHVBK 20210128100519.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0489-6 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0489-6 Use of vessel patterns on contrast-enhanced ultrasonography using a perflubutane-based contrast agent for the differential diagnosis of regenerative nodules from early hepatocellular carcinoma or high-grade dysplastic nodules in patients with chronic liver disease [Elektronische Daten] [Kazushi Numata, Hiroyuki Fukuda, Hiromi Nihonmatsu, Masaaki Kondo, Akito Nozaki, Makoto Chuma, Manabu Morimoto, Takashi Oshima, Masahiro Okada, Takamichi Murakami, Shigeo Takebayashi, Shin Maeda, Yoshiaki Inayama, Masayuki Nakano, Katsuaki Tanaka] Objective: We evaluated the use of tumor vessel patterns observed during arterial-phase contrast-enhanced ultrasonography (US) to differentiate regenerative nodules (RN) from early hepatocellular carcinoma (HCC) or high-grade dysplastic nodules (HGDN) in patients with chronic liver disease. Subjects and methods: Pathologically confirmed lesions (83 early HCC, 6 HGDN, and 13 RN with mean maximal diameters of 15.4, 15.3, and 16.2mm, respectively) were enrolled in this retrospective study. We performed contrast-enhanced US using a perflubutane-based contrast agent. We then classified the tumor vessels observed during the arterial phase of contrast-enhanced US into two patterns: peripheral vessels (centripetal pattern) and central vessels (centrifugal pattern). Results: Eighty-one (97.6%) of the 83 early HCC exhibited various enhancement patterns (hypovascular, 44.6%; isovascular, 25.3%; and hypervascular, 27.7%) and a peripheral vessel pattern, while the remaining 2 lesions (2.4%) exhibited hypovascular enhancement and a central vessel pattern. All 6 HGDN lesions were hypovascular with a peripheral vessel pattern. Twelve (92.3%) of the 13 RN were hypovascular with a central vessel pattern, and the remaining one (7.7%) was hypervascular with a central vessel pattern. When lesions exhibiting a central vessel pattern during arterial-phase contrast-enhanced US were diagnosed as RN, the sensitivity, specificity, and accuracy of these diagnoses were 100%, 97.8%, and 98.0%, respectively. Conclusion: The tumor vessel patterns observed during arterial-phase contrast-enhanced US may be useful for differentiating RN from early HCC or HGDN in patients with chronic liver disease. Springer Science+Business Media New York, 2015 Contrast-enhanced ultrasonography nationallicence Early hepatocellular carcinoma nationallicence Regenerative nodule nationallicence High-grade dysplastic nodule nationallicence Tumor vessel nationallicence Numata Kazushi Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut Fukuda Hiroyuki Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut Nihonmatsu Hiromi Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut Kondo Masaaki Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut Nozaki Akito Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut Chuma Makoto Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut Morimoto Manabu Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut Oshima Takashi Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut Okada Masahiro Department of Radiology, University Hospital of the Ryukyus, 207 Azakamihara, Nishihara-cho, 903-0215, Nakagami-gun, Okinawa, Japan aut Murakami Takamichi Department of Radiology, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi, 589-8511, Osaka-Sayama, Osaka, Japan aut Takebayashi Shigeo Department of Radiology, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut Maeda Shin Division of Gastroenterology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Kanagawa, Japan aut Inayama Yoshiaki Department of Pathology, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut Nakano Masayuki Pathological Department, Shonan Fujisawa Tokusyukai Hospital, 1-5-1 Kamidai, Tusjido, 251-0041, Fujisawa, Kanagawa, Japan aut Tanaka Katsuaki Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2372-2383 0942-8925 40:7<2372 2015 40 261 https://doi.org/10.1007/s00261-015-0489-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0489-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Numata Kazushi Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Fukuda Hiroyuki Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Nihonmatsu Hiromi Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Kondo Masaaki Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Nozaki Akito Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Chuma Makoto Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Morimoto Manabu Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Oshima Takashi Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Okada Masahiro Department of Radiology, University Hospital of the Ryukyus, 207 Azakamihara, Nishihara-cho, 903-0215, Nakagami-gun, Okinawa, Japan aut NATIONALLICENCE 700 1- Murakami Takamichi Department of Radiology, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi, 589-8511, Osaka-Sayama, Osaka, Japan aut NATIONALLICENCE 700 1- Takebayashi Shigeo Department of Radiology, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Maeda Shin Division of Gastroenterology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Inayama Yoshiaki Department of Pathology, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Nakano Masayuki Pathological Department, Shonan Fujisawa Tokusyukai Hospital, 1-5-1 Kamidai, Tusjido, 251-0041, Fujisawa, Kanagawa, Japan aut NATIONALLICENCE 700 1- Tanaka Katsuaki Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2372-2383 0942-8925 40:7<2372 2015 40 261