caa a22 4500 605493332 CHVBK 20210128100520.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0396-x doi (NATIONALLICENCE)springer-10.1007/s00261-015-0396-x Short-term reproducibility of apparent diffusion coefficient estimated from diffusion-weighted MRI of the prostate [Elektronische Daten] [Meredith Sadinski, Milica Medved, Ibrahim Karademir, Shiyang Wang, Yahui Peng, Yulei Jiang, Steffen Sammet, Gregory Karczmar, Aytekin Oto] Purpose: The purpose of the study is to determine short-term reproducibility of apparent diffusion coefficient (ADC) estimated from diffusion-weighted magnetic resonance (DW-MR) imaging of the prostate. Methods: Fourteen patients with biopsy-proven prostate cancer were studied under an Institutional Review Board-approved protocol. Each patient underwent two, consecutive and identical DW-MR scans on a 3T system. ADC values were calculated from each scan and a deformable registration was performed to align corresponding images. The prostate and cancerous regions of interest (ROIs) were independently analyzed by two radiologists. The prostate volume was analyzed by sextant. Per-voxel absolute and relative percentage variations in ADC were compared between sextants. Per-voxel and per-ROI variations in ADC were calculated for cancerous ROIs. Results: Per-voxel absolute difference in ADC in the prostate ranged from 0 to 1.60×10−3 mm2/s (per-voxel relative difference 0% to 200%, mean 10.5%). Variation in ADC was largest in the posterior apex (0% to 200%, mean 11.6%). Difference in ADC variation between sextants was not statistically significant. Cancer ROIs' per-voxel variation in ADC ranged from 0.001×10−3 to 0.841×10−3 mm2/s (0% to 67.4%, mean 11.2%) and per-ROI variation ranged from 0 to 0.463×10−3 mm2/s (mean 0.122×10−3 mm2/s). Conclusions: Variation in ADC within the human prostate is reasonably small, and is on the order of 10%. Springer Science+Business Media New York, 2015 DWI nationallicence ADC nationallicence Prostate nationallicence Reproducibility nationallicence MRI nationallicence Sadinski Meredith Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut Medved Milica Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut Karademir Ibrahim Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut Wang Shiyang Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut Peng Yahui Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut Jiang Yulei Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut Sammet Steffen Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut Karczmar Gregory Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut Oto Aytekin Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2523-2528 0942-8925 40:7<2523 2015 40 261 https://doi.org/10.1007/s00261-015-0396-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0396-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sadinski Meredith Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Medved Milica Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Karademir Ibrahim Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Wang Shiyang Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Peng Yahui Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Jiang Yulei Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Sammet Steffen Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Karczmar Gregory Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Oto Aytekin Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, 60637, Chicago, IL, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2523-2528 0942-8925 40:7<2523 2015 40 261