caa a22 4500 605493421 CHVBK 20210128100520.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0466-0 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0466-0 The influence of anti-TNF therapy on the magnetic resonance enterographic parameters of Crohn's disease activity [Elektronische Daten] [Piotr Eder, Katarzyna Katulska, Iwona Krela-Kaźmierczak, Kamila Stawczyk-Eder, Katarzyna Klimczak, Aleksandra Szymczak, Krzysztof Linke, Liliana Łykowska-Szuber] Purpose: Magnetic resonance enterography (MRE) is a useful tool in assessing the transmural and extraintestinal lesions in Crohn's disease (CD). However, the influence of anti-tumor necrosis factor (anti-TNF) therapy on MRE features of CD severity remains unknown. The purpose of the study was to assess the short- and long-term changes in MRE features of CD activity in relation to CD clinical course in patients treated with anti-TNF antibodies. Methods: The influence on the most important parameters of CD activity seen in MRE was assessed retrospectively using a validated score. Patients were treated with anti-TNF agents and the clinical, laboratory, and MRE CD activity was estimated at baseline, after the induction therapy and after 1year of treatment. Results: 71 patients were enrolled in a study. The change in CD clinical activity correlated significantly with fluctuations in MRE activity score (P<0.0001, r=0.5 for induction; P=0.004, r=0.7 for maintenance anti-TNF therapy, respectively). Bowel wall thickening, mesenteric lymphadenopathy, and fat wrapping with vascular proliferation were MRE parameters which changed significantly both after the induction and maintenance treatment in patients responding to the therapy. The change in MRE activity score was mostly pronounced during the first 3months of treatment, when compared to the continuation of the therapy till week 52-54 (−6 points vs. −2 points, respectively; P=0.0008). Conclusions: Transmural and extraintestinal healing seen in MRE correlates with changes in CD clinical activity during anti-TNF therapy, thus MRE seems to be a useful tool in monitoring the efficacy of biological agents. The Author(s), 2015 Anti-tumor necrosis factor alpha therapy nationallicence Crohn's disease nationallicence Magnetic resonance enterography nationallicence Eder Piotr Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland aut Katulska Katarzyna Department of General Radiology, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland aut Krela-Kaźmierczak Iwona Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland aut Stawczyk-Eder Kamila Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland aut Klimczak Katarzyna Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland aut Szymczak Aleksandra Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland aut Linke Krzysztof Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland aut Łykowska-Szuber Liliana Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2210-2218 0942-8925 40:7<2210 2015 40 261 https://doi.org/10.1007/s00261-015-0466-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0466-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Eder Piotr Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland aut NATIONALLICENCE 700 1- Katulska Katarzyna Department of General Radiology, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland aut NATIONALLICENCE 700 1- Krela-Kaźmierczak Iwona Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland aut NATIONALLICENCE 700 1- Stawczyk-Eder Kamila Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland aut NATIONALLICENCE 700 1- Klimczak Katarzyna Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland aut NATIONALLICENCE 700 1- Szymczak Aleksandra Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland aut NATIONALLICENCE 700 1- Linke Krzysztof Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland aut NATIONALLICENCE 700 1- Łykowska-Szuber Liliana Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2210-2218 0942-8925 40:7<2210 2015 40 261