caa a22 4500 605493472 CHVBK 20210128100521.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0452-6 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0452-6 Adrenal 131I-6β-iodomethylnorcholesterol scintigraphy in choosing the side for adrenalectomy in bilateral adrenal tumors with subclinical hypercortisolemia [Elektronische Daten] [Lucyna Papierska, Jarosław Ćwikła, Michał Rabijewski, Piotr Glinicki, Maciej Otto, Anna Kasperlik-Załuska] Purpose: Adrenal scintigraphy with 131I-6β-iodomethylnorcholesterol is considered by several authors the gold standard for assessing tumors with subclinical hypercortisolemia. However, most of the described series consist mainly of cases with unilateral lesions. The aim of our study was to assess whether scintigraphy is useful in choosing the adrenalectomy side in the case of bilateral adrenal tumors with subclinical hypercortisolemia. Methods: The study focused on 15 consecutive patients with benign bilateral adrenal tumors and subclinical hypercortisolemia. The scintigraphy with 131I-6β-iodomethylnorcholesterol was performed. Fourteen patients underwent unilateral adrenalectomy; the gland with predominant uptake on scintigraphy was removed. Cortisol and ACTH concentrations were measured one and six months after surgery. Post-dexamethasone cortisolemia was assessed six months after surgery. To date, the patients have been under postoperative observation for 1-4 years. Results: Four patients showed unilateral uptake of radiotracer, and nine patients showed predominant accumulation of radiotracer in one of the adrenal glands. The smaller tumor was predominant in 2 cases. Percentage of activity on the predominant side correlates positively with the difference between tumors' diameters. Unilateral uptake of radiotracer predicts long-lasting postoperative insufficiency of the second adrenal gland. Excision of predominating tumor led to cessation of hypercortisolemia in all patients. Conclusions: The corticoadrenal scintigraphy is useful in choosing the side for operation in the case of bilateral adrenal tumors with subclinical hypercortisolemia. The Author(s), 2015 Adrenal scintigraphy nationallicence Bilateral adrenal tumors nationallicence Iodomethylnorcholesterol scintigraphy nationallicence Subclinical hypercortisolemia nationallicence Papierska Lucyna Department of Endocrinology, Medical Center of Postgraduate Education, CMKP, ul. Marymoncka 99, 01-809, Warsaw, Poland aut Ćwikła Jarosław Department of Radiology, The Faculty of Medical Sciences, University of Warmia and Mazury, Uniwersytet Warmińsko-Mazurski, ul. Warszawska 30, 10-082, Olsztyn, Poland aut Rabijewski Michał Department of Internal Diseases, Diabetology and Endocrinology, Medical University of Warsaw, Mazowiecki Szpital Bródnowski, ul. Kondratowicza 8, 03-242, Warsaw, Poland aut Glinicki Piotr Department of Endocrinology, Medical Center of Postgraduate Education, CMKP, ul. Marymoncka 99, 01-809, Warsaw, Poland aut Otto Maciej Department of General, Vascular and Transplant Surgery, Medical University of Warsaw, CSKUM, ul. Banacha 1a, 02-097, Warsaw, Poland aut Kasperlik-Załuska Anna Department of Endocrinology, Medical Center of Postgraduate Education, CMKP, ul. Marymoncka 99, 01-809, Warsaw, Poland aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2453-2460 0942-8925 40:7<2453 2015 40 261 https://doi.org/10.1007/s00261-015-0452-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0452-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Papierska Lucyna Department of Endocrinology, Medical Center of Postgraduate Education, CMKP, ul. Marymoncka 99, 01-809, Warsaw, Poland aut NATIONALLICENCE 700 1- Ćwikła Jarosław Department of Radiology, The Faculty of Medical Sciences, University of Warmia and Mazury, Uniwersytet Warmińsko-Mazurski, ul. Warszawska 30, 10-082, Olsztyn, Poland aut NATIONALLICENCE 700 1- Rabijewski Michał Department of Internal Diseases, Diabetology and Endocrinology, Medical University of Warsaw, Mazowiecki Szpital Bródnowski, ul. Kondratowicza 8, 03-242, Warsaw, Poland aut NATIONALLICENCE 700 1- Glinicki Piotr Department of Endocrinology, Medical Center of Postgraduate Education, CMKP, ul. Marymoncka 99, 01-809, Warsaw, Poland aut NATIONALLICENCE 700 1- Otto Maciej Department of General, Vascular and Transplant Surgery, Medical University of Warsaw, CSKUM, ul. Banacha 1a, 02-097, Warsaw, Poland aut NATIONALLICENCE 700 1- Kasperlik-Załuska Anna Department of Endocrinology, Medical Center of Postgraduate Education, CMKP, ul. Marymoncka 99, 01-809, Warsaw, Poland aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2453-2460 0942-8925 40:7<2453 2015 40 261