caa a22 4500 605493510 CHVBK 20210128100521.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0445-5 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0445-5 Intrahepatic mass-forming cholangiocarcinoma: enhancement pattern on Gd-BOPTA-MRI with emphasis of hepatobiliary phase [Elektronische Daten] [Giuseppe Mamone, Gianluca Marrone, Settimo Caruso, Vincenzo Carollo, Giovanni Gentile, Francesca Crino', Mariapina Milazzo, Angelo Luca] Purpose: To describe the Gd-BOPTA MRI findings of intrahepatic mass-forming type cholangiocarcinomas (IMCs), with emphasis on the hepatobiliary phase (HBP). Methods: We reviewed retrospectively 29 IMC patients who underwent Gd-BOPTA-MRI between June, 2004 and June, 2014. Images were acquired prior to, and after, administration of 15-20mL of Gd-BOPTA in the dynamic phase (arterial phase, portal venous phase, and 3-5min phase), 10-15-min late phase, and 2-3h HBP phase. Results: In the dynamic phase, 27 (93%) lesions showed a peripheral rim-like enhancement in the arterial and portal venous phases, followed by progressive filling-in on the delayed images. In 14 (56%) cases, a hypointense peripheral rim was identified in the 10-15-min late phase, delineating a target pattern. In the HBP, the cholangiocarcinoma showed a diffuse, mainly central and inhomogeneous enhancement (cloud of enhancement) in 28 (96%) patients; in 23 (79%) cases, there was an association between cloud appearance and a hypointense peripheral rim, showing a target pattern. Conclusions: Gd-BOPTA MRI pattern of IMC on dynamic study is similar to that of conventional extracellular agents, that is peripheral enhancement with progressive and concentric filling of contrast material on delayed phases. At 10-15min delayed phases, IMC shows often a peripheral hypointense rim consistent with a target appearance. In the HBP, due to progressive central enhancement (cloud) and peripheral hypointense rim, an higher number of tumors show a target appearance; this pattern is not specific and would also be expected to be seen in metastases from adenocarcinoma. Springer Science+Business Media New York, 2015 Intrahepatic mass-forming cholangiocarcinoma (IMC) nationallicence Liver nationallicence MRI nationallicence Gd-BOPTA nationallicence Hepatobiliary phase (HBP) nationallicence IMC : Intrahepatic mass-forming cholangiocarcinoma nationallicence HBP : Hepatobiliary phase nationallicence Mamone Giuseppe Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) - University of Pittsburgh Medical Center (UPMC), Via Ernesto Tricomi 5, 90127, Palermo, Italy aut Marrone Gianluca Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) - University of Pittsburgh Medical Center (UPMC), Via Ernesto Tricomi 5, 90127, Palermo, Italy aut Caruso Settimo Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) - University of Pittsburgh Medical Center (UPMC), Via Ernesto Tricomi 5, 90127, Palermo, Italy aut Carollo Vincenzo Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) - University of Pittsburgh Medical Center (UPMC), Via Ernesto Tricomi 5, 90127, Palermo, Italy aut Gentile Giovanni Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) - University of Pittsburgh Medical Center (UPMC), Via Ernesto Tricomi 5, 90127, Palermo, Italy aut Crino' Francesca Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) - University of Pittsburgh Medical Center (UPMC), Via Ernesto Tricomi 5, 90127, Palermo, Italy aut Milazzo Mariapina Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) - University of Pittsburgh Medical Center (UPMC), Via Ernesto Tricomi 5, 90127, Palermo, Italy aut Luca Angelo Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) - University of Pittsburgh Medical Center (UPMC), Via Ernesto Tricomi 5, 90127, Palermo, Italy aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2313-2322 0942-8925 40:7<2313 2015 40 261 https://doi.org/10.1007/s00261-015-0445-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0445-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mamone Giuseppe Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) - University of Pittsburgh Medical Center (UPMC), Via Ernesto Tricomi 5, 90127, Palermo, Italy aut NATIONALLICENCE 700 1- Marrone Gianluca Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) - University of Pittsburgh Medical Center (UPMC), Via Ernesto Tricomi 5, 90127, Palermo, Italy aut NATIONALLICENCE 700 1- Caruso Settimo Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) - University of Pittsburgh Medical Center (UPMC), Via Ernesto Tricomi 5, 90127, Palermo, Italy aut NATIONALLICENCE 700 1- Carollo Vincenzo Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) - University of Pittsburgh Medical Center (UPMC), Via Ernesto Tricomi 5, 90127, Palermo, Italy aut NATIONALLICENCE 700 1- Gentile Giovanni Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) - University of Pittsburgh Medical Center (UPMC), Via Ernesto Tricomi 5, 90127, Palermo, Italy aut NATIONALLICENCE 700 1- Crino' Francesca Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) - University of Pittsburgh Medical Center (UPMC), Via Ernesto Tricomi 5, 90127, Palermo, Italy aut NATIONALLICENCE 700 1- Milazzo Mariapina Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) - University of Pittsburgh Medical Center (UPMC), Via Ernesto Tricomi 5, 90127, Palermo, Italy aut NATIONALLICENCE 700 1- Luca Angelo Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) - University of Pittsburgh Medical Center (UPMC), Via Ernesto Tricomi 5, 90127, Palermo, Italy aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2313-2322 0942-8925 40:7<2313 2015 40 261