caa a22 4500 605493529 CHVBK 20210128100521.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0442-8 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0442-8 Liver parenchyma at the site of hypodense parafissural pseudolesion contains increased collagen [Elektronische Daten] [Lianne Sonnemans, Nils Köster, Mathias Prokop, Jeroen van der Laak, Willemijn Klein] Purpose: To identify a histological substrate explaining the hypodense pseudolesion in the liver at the right side of the falciform ligament and the correlation with CT radiodensity. Materials and methods: Tissue specimens were obtained from the right (pseudolesion) and left (control) side of the falciform ligament at the level of the left portal vein, in deceased adults during autopsy. Radiodensity was measured at the same locations at CT. Digital image analysis determined the amount of collagen and fat in histological sections, and the number of portal triads and central veins were counted. Glycogen content was visually assessed by the area percentage of the histological section. Results: Specimens from 17 patients showed a 39% increase in collagen for the site of the pseudolesion compared to the contralateral side (p=0.08). No significant differences were found for the amount of fat, glycogen, portal triads, or central veins. In one patient a pseudolesion was visible on CT, and this contained 52% more collagen than the control side. Conclusion: The pseudolesion at the right parafissural side in the liver contains more collagen compared to the control left side, while there is no difference in fat or glycogen content or number of portal and hepatic veins. Collagen may be the cause of the pseudolesion. Springer Science+Business Media New York, 2015 Liver nationallicence Computer tomography nationallicence Pseudolesion nationallicence Histology nationallicence CT : Computed tomography nationallicence MRI : Magnetic resonance imaging nationallicence PAS : Periodic acid Schiff nationallicence HE : Hematoxylin and eosin nationallicence EVG : Elastin Van Gieson nationallicence HU : Hounsfield unit nationallicence PMI : Post-mortem interval nationallicence ICC : Intraclass correlation coefficient nationallicence Sonnemans Lianne Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut Köster Nils Department of Pathology, Radboud University Medical Centre, Nijmegen, The Netherlands aut Prokop Mathias Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut van der Laak Jeroen Department of Pathology, Radboud University Medical Centre, Nijmegen, The Netherlands aut Klein Willemijn Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2306-2312 0942-8925 40:7<2306 2015 40 261 https://doi.org/10.1007/s00261-015-0442-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0442-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sonnemans Lianne Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Köster Nils Department of Pathology, Radboud University Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Prokop Mathias Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- van der Laak Jeroen Department of Pathology, Radboud University Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Klein Willemijn Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2306-2312 0942-8925 40:7<2306 2015 40 261