Non-hyperfunctioning pancreatic endocrine tumors: multimodality imaging features with histopathological correlation
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| 008 | 210128e20151001xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00261-015-0458-0 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-015-0458-0 | ||
| 245 | 0 | 0 | |a Non-hyperfunctioning pancreatic endocrine tumors: multimodality imaging features with histopathological correlation |h [Elektronische Daten] |c [Peter Humphrey, Francesco Alessandrino, Andrew Bellizzi, Koenraad Mortele] |
| 520 | 3 | |a Purpose: To evaluate the multimodality imaging features of non-hyperfunctioning pancreatic endocrine tumors (NF-PNET) with histopathological correlation. Methods: Preoperative imaging (CT: n=23; MRI: n=14; 111In-octreotide: n=8) of 28 patients (17 female; mean age 55years) with resected NF-PNET were evaluated for tumor location, size, morphology, attenuation/signal intensity, 111In-octreotide uptake, cystic degeneration, and enhancement. Tissue specimens were assessed for the extent of stromal fibrosis, vascular density, presence of a fibrous pseudocapsule, and tumor grading. Correlation between imaging and histopathology was made using the Fisher-Freeman-Halton exact test. Results: NF-PNET arose from the pancreatic head/neck (n=10), body (n=7), and tail (n=11). On CT, NF-PNET (mean largest diameter: 4.4cm) appeared predominantly solid (69.6%), well defined (91.3%), and oval (47.8%) in shape. In the late arterial phase, NF-PNET appeared mainly hypovascular (55.5%). Septations (30.4%) and calcifications (21.7%) were relatively uncommon. On MRI, NF-PNET (mean size: 2.6cm) appeared most commonly as solid (57.1%), encapsulated (71.4%), oval (64.2%) lesions that were hyperintense on T2-WI (64.3%), and hypo- or isovascular to pancreas (66.7%) during the late arterial phase. Cystic NF-PNET (3.8cm) were not significantly larger than solid (3.5cm) NF-PNET (CT, p=0.758; MRI, p=0.451). 111In-octreotide uptake was demonstrated in 5/8 (62.5%) patients. At histopathology, NF-PNET were predominantly encapsulated (69.2%); stromal fibrosis comprised <33% of the tumor (69.2%), and vascular density was average (46.1%). A significant association was demonstrated between the degree of fibrosis and hypointensity on T2-WI (p=0.003). Vascular density, tumor grade, and degree of fibrosis did not significantly relate to the pattern of enhancement. Conclusions: NF-PNETs have variable imaging appearances but are most commonly oval shaped, solid, and well-defined/encapsulated masses, and hypovascular on late arterial and portal venous phase. Cystic degeneration in NF-PNET appears independent of tumor size. Low signal intensity on T2-WI correlates with extensive intratumoral fibrosis. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Pancreas |2 nationallicence | |
| 690 | 7 | |a Neuroendocrine tumors |2 nationallicence | |
| 690 | 7 | |a Non-hyperfunctioning neuroendocrine tumors |2 nationallicence | |
| 690 | 7 | |a Magnetic resonance imaging |2 nationallicence | |
| 690 | 7 | |a Multidetector computed tomography |2 nationallicence | |
| 690 | 7 | |a Somatostatin receptor scintigraphy |2 nationallicence | |
| 700 | 1 | |a Humphrey |D Peter |u Northwest Imaging, Kalispell Regional Medical Center, 59901, Kalispell, MT, USA |4 aut | |
| 700 | 1 | |a Alessandrino |D Francesco |u Division of Body MRI, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Ansin 224, 02215, Boston, MA, USA |4 aut | |
| 700 | 1 | |a Bellizzi |D Andrew |u Department of Pathology, University of Iowa Carver College of Medicine, 52242, Iowa City, IA, USA |4 aut | |
| 700 | 1 | |a Mortele |D Koenraad |u Division of Abdominal Imaging and Intervention, Department of Radiology, Brigham & Women's Hospital, Harvard Medical School, 02115, Boston, MA, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/7(2015-10-01), 2398-2410 |x 0942-8925 |q 40:7<2398 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-015-0458-0 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-015-0458-0 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Humphrey |D Peter |u Northwest Imaging, Kalispell Regional Medical Center, 59901, Kalispell, MT, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Alessandrino |D Francesco |u Division of Body MRI, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Ansin 224, 02215, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bellizzi |D Andrew |u Department of Pathology, University of Iowa Carver College of Medicine, 52242, Iowa City, IA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mortele |D Koenraad |u Division of Abdominal Imaging and Intervention, Department of Radiology, Brigham & Women's Hospital, Harvard Medical School, 02115, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/7(2015-10-01), 2398-2410 |x 0942-8925 |q 40:7<2398 |1 2015 |2 40 |o 261 | ||