caa a22 4500 605493707 CHVBK 20210128100522.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0412-1 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0412-1 Lowering radiation dose during dedicated colorectal cancer MDCT: comparison of low tube voltage and sinogram-affirmed iterative reconstruction at 80kVp versus blended dual-energy images in a population of patients with low body mass index [Elektronische Daten] [Chiao-Yun Chen, Jui-Sheng Hsu, Twei-Shiun Jaw, Yu-Ting Kuo, Deng-Chyang Wu, Chien-Hung Lee, Ming-Chen Shih, Tzu-Hsueh Tsai, Chao-Hung Kuo, Yi-Ting Chen, Li-Hwa Yang, Gin-Chung Liu] Purpose: To assess the diagnostic accuracy, cancer staging, image quality, and radiation dose of 80-kVp computed tomography (CT) images for patients with colorectal cancers (CRCs) using sinogram-affirmed iterative reconstruction (SAFIRE). Methods: Sixty-four consecutive patients (mean weight 62.5 ± 11.3kg, mean BMI 24.1 ± 3.3kg/m2) with known CRC underwent dual-energy CT. Data were reconstructed as a weighted average (WA) 120-kVp dataset. Both filtered back projection (FBP) and SAFIRE were applied to reconstruct the WA 120-Kvp (Protocol A, B) and 80-kVp (Protocol C, D) image sets. The image noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) of the cancers, the normal reference tissues, and the effective dose for each protocol were assessed. The cancer detection, staging, and image quality were evaluated. Analysis of variance was used for statistical analysis. Results: Compared with the FBP datasets at WA 120-kVp (Protocol A) and 80-kVp (Protocol C), the SAFIRE-reconstructed images (Protocols B, D) demonstrated significantly lower image noise (P < 0.0083). Protocol D yielded significantly higher CNRs and SNRs for the CRCs and normal reference tissues than did Protocols A and C (P < 0.0083). Protocol D also exhibited a significantly higher CNR for the CRC and some normal reference tissues than did Protocol B (P < 0.0083). For hypovascular liver metastases (n = 10), Protocol D yielded better SNRs and significantly higher CNRs than did Protocol A (P < 0.0083). Overall, accuracy for tumor staging and liver metastasis was 95.3% (61/64) and 100%, respectively, in all of the 4 protocols. The mean effective dose decreased 41% from the WA 120-kVp to the 80-kVp protocols (6.23 vs. 3.68mSv). Conclusions: The 80-kVp technique with SAFIRE provided high SNR, high CNR, and good accuracy for staging in nonobese patients with CRC. Our study results should be extrapolated to patient populations with a high BMI with caution. Further studies of high BMI patients are therefore warranted. Springer Science+Business Media New York, 2015 Dual-energy CT nationallicence Colorectal cancer nationallicence Low-radiation-dose technique nationallicence Sinogram-affirmed iterative reconstruction (SAFIRE) nationallicence Filtered back projection (FBP) nationallicence Abdomen nationallicence Chen Chiao-Yun Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut Hsu Jui-Sheng Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut Jaw Twei-Shiun Department of Radiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut Kuo Yu-Ting Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan aut Wu Deng-Chyang Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut Lee Chien-Hung Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan aut Shih Ming-Chen Department of Radiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut Tsai Tzu-Hsueh Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan aut Kuo Chao-Hung Department of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut Chen Yi-Ting Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan aut Yang Li-Hwa Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan aut Liu Gin-Chung Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2867-2876 0942-8925 40:7<2867 2015 40 261 https://doi.org/10.1007/s00261-015-0412-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0412-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Chiao-Yun Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Hsu Jui-Sheng Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Jaw Twei-Shiun Department of Radiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Kuo Yu-Ting Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Wu Deng-Chyang Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Lee Chien-Hung Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Shih Ming-Chen Department of Radiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Tsai Tzu-Hsueh Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Kuo Chao-Hung Department of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Chen Yi-Ting Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Yang Li-Hwa Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Liu Gin-Chung Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2867-2876 0942-8925 40:7<2867 2015 40 261