caa a22 4500 605493715 CHVBK 20210128100522.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0451-7 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0451-7 Assessing splenic enlargement on CT by unidimensional measurement changes in patients with colorectal liver metastases [Elektronische Daten] [Breanna Joiner, Amber Simpson, Julie Leal, Michael D'Angelica, Richard Do] Purpose: The aim of this study was to assess splenic volume and to correlate unidimensional measurements with reference volumetric changes in chemotherapy-treated patients with colorectal cancer (CRC) liver metastases. Methods: Forty consecutive patients were selected from the cohort of a previously reported study of chemotherapy-related morbidity following major hepatectomy for CRC liver metastases. Patients were treated for 6months prior to resection, with imaging performed at baseline and after 6months of chemotherapy. Three unidimensional spleen measurements were recorded—width, thickness, and height (W, T, and H). Reference splenic volume was measured at baseline and after chemotherapy. The best unidimensional splenic measurement was determined by regression analysis. The 95% CI for the predicted values and R 2 values was calculated for each regression. The percentage of volume increase at 6months was calculated. Results: W and H showed the highest correlation with splenic volume prior to and following chemotherapy (R 2=0.65-0.74, p<0.001), while T showed a low correlation (R 2=0.11 and 0.18, p<0.05). The mean reference splenic volume increased after 6months of chemotherapy compared to baseline (326 vs. 278mL). Splenic volume changes showed the highest correlation with changes in W (R 2=0.56, p<0.001), then H (R 2=0.40, p<0.001), but were not significantly correlated with changes in T (R 2=0.01, p=0.055). Conclusions: Our results show the potential utility of measuring changes in splenic width to predict clinically significant changes in splenic volume in chemotherapy-treated patients with CRC liver metastases. Springer Science+Business Media New York, 2015 Splenic volume nationallicence Splenomegaly nationallicence Colorectal cancer liver metastases nationallicence Hepatectomy nationallicence CT imaging nationallicence Chemotherapy nationallicence Joiner Breanna Sophie Davis School of Biomedical Education, The City College of New York, 160 Convent Ave, 10031, New York, NY, USA aut Simpson Amber Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, 10065, New York, NY, USA aut Leal Julie Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, 10065, New York, NY, USA aut D'Angelica Michael Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, 10065, New York, NY, USA aut Do Richard Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, 10065, New York, NY, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2338-2344 0942-8925 40:7<2338 2015 40 261 https://doi.org/10.1007/s00261-015-0451-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0451-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Joiner Breanna Sophie Davis School of Biomedical Education, The City College of New York, 160 Convent Ave, 10031, New York, NY, USA aut NATIONALLICENCE 700 1- Simpson Amber Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, 10065, New York, NY, USA aut NATIONALLICENCE 700 1- Leal Julie Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, 10065, New York, NY, USA aut NATIONALLICENCE 700 1- D'Angelica Michael Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, 10065, New York, NY, USA aut NATIONALLICENCE 700 1- Do Richard Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, 10065, New York, NY, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2338-2344 0942-8925 40:7<2338 2015 40 261