caa a22 4500 605493731 CHVBK 20210128100522.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0438-4 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0438-4 CT textural analysis of hepatic metastatic colorectal cancer: pre-treatment tumor heterogeneity correlates with pathology and clinical outcomes [Elektronische Daten] [Meghan Lubner, Nicholas Stabo, Sam Lubner, Alejandro del Rio, Chihwa Song, Richard Halberg, Perry Pickhardt] Purpose: The purpose of the study was to determine if CT texture features of untreated hepatic metastatic colorectal cancer (CRC) relate to pathologic features and clinical outcomes. Methods: Tumor texture analysis was performed on single hepatic metastatic lesions on pre-treatment contrast-enhanced CT scans in 77 pts (mean age 58, 34F/43M) using a novel tool. Measures of heterogeneity, including entropy, kurtosis, skewness, mean, mean positive pixels (MPP), and standard deviation (SD) of pixel distribution histogram were derived with filter values corresponding to fine (spatial scaling factor (ssf) 2), medium (ssf 3, 4), and coarse textures (ssf 5, 6). Texture parameters were correlated with tumor grade, baseline serum CEA, and KRAS mutation status. Overall survival was also correlated using Cox proportional hazards models. Single-slice 2D vs. whole-tumor volumetric 3D texture analysis was compared in a subcohort of 20 patients. Results: Entropy, MPP, and SD at medium filtration levels were significantly associated with tumor grade (MPP ssf 3 P=0.002, SD ssf 3 P=0.004, entropy ssf 4 P=0.007). Skewness was negatively associated KRAS mutation (P=0.02). Entropy at coarse filtration levels was associated with survival (Hazard ratio (HR) for death 0.65, 95% CI 0.44-0.95, P=0.03). Texture results for 2D and 3D analysis were similar. Conclusions: CT texture features, particularly entropy, MPP, and SD, are significantly associated with tumor grade in untreated CRC liver metastases. Tumor entropy at coarse filters correlates with overall survival. Single-slice 2D texture analysis appears to be adequate. Springer Science+Business Media New York, 2015 CT nationallicence Texture nationallicence Heterogeneity nationallicence Colorectal cancer nationallicence Metastases nationallicence Lubner Meghan Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792, Madison, WI, USA aut Stabo Nicholas Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792, Madison, WI, USA aut Lubner Sam Department of Internal Medicine (Sections Human Oncology and Gastroenterology), University of Wisconsin School of Medicine and Public Health, Madison, WI, USA aut del Rio Alejandro Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792, Madison, WI, USA aut Song Chihwa Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA aut Halberg Richard Department of Internal Medicine (Sections Human Oncology and Gastroenterology), University of Wisconsin School of Medicine and Public Health, Madison, WI, USA aut Pickhardt Perry Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792, Madison, WI, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2331-2337 0942-8925 40:7<2331 2015 40 261 https://doi.org/10.1007/s00261-015-0438-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0438-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lubner Meghan Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792, Madison, WI, USA aut NATIONALLICENCE 700 1- Stabo Nicholas Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792, Madison, WI, USA aut NATIONALLICENCE 700 1- Lubner Sam Department of Internal Medicine (Sections Human Oncology and Gastroenterology), University of Wisconsin School of Medicine and Public Health, Madison, WI, USA aut NATIONALLICENCE 700 1- del Rio Alejandro Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792, Madison, WI, USA aut NATIONALLICENCE 700 1- Song Chihwa Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA aut NATIONALLICENCE 700 1- Halberg Richard Department of Internal Medicine (Sections Human Oncology and Gastroenterology), University of Wisconsin School of Medicine and Public Health, Madison, WI, USA aut NATIONALLICENCE 700 1- Pickhardt Perry Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, 53792, Madison, WI, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2331-2337 0942-8925 40:7<2331 2015 40 261