caa a22 4500 605493820 CHVBK 20210128100522.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0424-x doi (NATIONALLICENCE)springer-10.1007/s00261-015-0424-x Variable color Doppler sonographic appearances of retained products of conception: radiologic-pathologic correlation [Elektronische Daten] [Aya Kamaya, Priya Krishnarao, Ann Folkins, R. Jeffrey, Terry Desser, Katherine Maturen] Object of study: Retained products of conception (RPOC) displays variable vascularity, ranging from avascular to markedly vascular on color Doppler sonography. We hypothesize that variability in sonographic vascularity may be due to histopathologic variation in the placental tissue. Materials, methods, and procedures: After institutional review board approval, sonographic images and pathologic specimens were retrospectively reviewed in 26 patients with pathologically proven RPOC. Ultrasound (US) images were scored 0-3 for the degree of vascularity by two radiologists blinded to the diagnosis. Corresponding pathologic specimens were evaluated for vascularization of chorionic villi, degree of inflammation, morphology of maternal arteries, chorionic villous preservation, and percentage of clot, membranes, chorionic villi, and decidua/myometrium. Statistical analysis, including multiple linear regression, was performed. Results: RPOC with histologically avascular chorionic villi or those with markedly reduced vascularization had significantly lower US vascularity scores (p=0.030) than those with chorionic villi showing normal or decreased vascularization. Sonographically avascular RPOC had a significantly lower percentage villi (p=0.028) and higher percentage of decidua (p=0.004) than specimens where US showed any Doppler vascularity. Histologic vascularity of villi (p=0.049) and non-observation of maternal arteries (p=0.001) were significant predictors of US vascularity scores in multivariate linear regression analysis, while inflammation of villi (p=0.053) was a marginally significant predictor. Significance of the conclusions: Histologic vascularity of villi appears to contribute to the observed variation in sonographic vascularity. This finding may underlie known differences in clinical outcomes between sonographic vascularity groups. Springer Science+Business Media New York, 2015 Retained products of conception nationallicence Residual trophoblastic disease nationallicence Arteriovenous malformation nationallicence Uterus nationallicence Kamaya Aya Stanford University Medical Center, 300 Pasteur Drive, 94305, Stanford, CA, USA aut Krishnarao Priya Santa Clara Valley Medical Center, 751 S. Bascom Avenue, 95128, San Jose, CA, USA aut Folkins Ann Stanford University Medical Center, 300 Pasteur Drive, 94305, Stanford, CA, USA aut Jeffrey R. Stanford University Medical Center, 300 Pasteur Drive, 94305, Stanford, CA, USA aut Desser Terry Stanford University Medical Center, 300 Pasteur Drive, 94305, Stanford, CA, USA aut Maturen Katherine University of Michigan, 1500 Medical Center Drive, 48104, Ann Arbor, MI, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2683-2689 0942-8925 40:7<2683 2015 40 261 https://doi.org/10.1007/s00261-015-0424-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0424-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kamaya Aya Stanford University Medical Center, 300 Pasteur Drive, 94305, Stanford, CA, USA aut NATIONALLICENCE 700 1- Krishnarao Priya Santa Clara Valley Medical Center, 751 S. Bascom Avenue, 95128, San Jose, CA, USA aut NATIONALLICENCE 700 1- Folkins Ann Stanford University Medical Center, 300 Pasteur Drive, 94305, Stanford, CA, USA aut NATIONALLICENCE 700 1- Jeffrey R. Stanford University Medical Center, 300 Pasteur Drive, 94305, Stanford, CA, USA aut NATIONALLICENCE 700 1- Desser Terry Stanford University Medical Center, 300 Pasteur Drive, 94305, Stanford, CA, USA aut NATIONALLICENCE 700 1- Maturen Katherine University of Michigan, 1500 Medical Center Drive, 48104, Ann Arbor, MI, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/7(2015-10-01), 2683-2689 0942-8925 40:7<2683 2015 40 261