caa a22 4500 605493928 CHVBK 20210128100523.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00261-014-0237-3 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0237-3 Prospective evaluation of CT indeterminate renal masses using US and contrast-enhanced ultrasound [Elektronische Daten] [Carlos Nicolau, Laura Buñesch, Blanca Paño, Rafael Salvador, Maria Ribal, Carme Mallofré, Carmen Sebastià] Objective: The aim of this study was to assess the accuracy of Ultrasound (US) and contrast-enhanced ultrasound (CEUS) in the characterization of renal nodules indeterminate on CT by identifying benign cystic lesions not requiring further examination. Methods: 72 patients with 83 indeterminate renal nodules on CT underwent baseline US and CEUS that classified lesions as benign (Bosniak I, II or IIF cysts) or potentially malignant (Bosniak III or IV cysts, solid nodules). The accuracy of US and CEUS in the differentiation between benign cysts and potentially malignant nodules was analyzed and compared with the final diagnosis obtained by histology or follow-up of at least 23months with CEUS ± a conclusive CT/MR study. Results: Final diagnoses comprised 50 benign complex cysts, 1 focal nephritis, 1 multilocular cystic nephroma, 3 oncocytomas, 1 transitional cell carcinoma and 27 renal cell carcinomas. Unenhanced US correctly classified 18/50 (36%) benign cysts and 17/33 (51.5%) of the potentially malignant lesions obtaining a sensitivity of 36%, specificity of 51.5%, and overall accuracy of 42.2%. The addition of CEUS allowed a correct diagnosis of 48 /50 (96%) benign cysts and of 31/33 (93.9%) nodules as potentially malignant, with a sensitivity of 96%, specificity of 93.9%, and overall accuracy of 95.2%. Conclusion: CEUS is very useful in the differentiation between benign complex cysts and other lesions that require further investigation in non-conclusive renal nodules detected on CT, improving the accuracy of baseline US from 42.2 to 95.2%. Springer Science+Business Media New York, 2014 Renal cancer nationallicence Renal mass nationallicence CT nationallicence Contrast-enhanced US nationallicence Nicolau Carlos Radiology Department, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut Buñesch Laura Radiology Department, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut Paño Blanca Radiology Department, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut Salvador Rafael Radiology Department, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut Ribal Maria Urology Department, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut Mallofré Carme Pathology Department, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut Sebastià Carmen Radiology Department, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/3(2015-03-01), 542-551 0942-8925 40:3<542 2015 40 261 https://doi.org/10.1007/s00261-014-0237-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0237-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nicolau Carlos Radiology Department, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Buñesch Laura Radiology Department, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Paño Blanca Radiology Department, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Salvador Rafael Radiology Department, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Ribal Maria Urology Department, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Mallofré Carme Pathology Department, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Sebastià Carmen Radiology Department, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/3(2015-03-01), 542-551 0942-8925 40:3<542 2015 40 261