caa a22 4500 605494029 CHVBK 20210128100524.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00261-014-0245-3 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0245-3 Comparison of re-biopsy with preceded MRI and re-biopsy without preceded MRI in patients with previous negative biopsy and persistently high PSA [Elektronische Daten] [Byung Park, Seong Jeon, Bumsoo Park, Jung Park, Chan Kim, Hyun Lee, Han Choi] Purpose: To retrospectively compare re-biopsy with preceded magnetic resonance imaging (MRI) and re-biopsy without preceded MRI. Materials and methods: Between January 2007 and May 2011, 669 patients (mean 64years; range 38-91years) underwent a re-biopsy because of previous negative biopsy (median 1; 1-5) and persistently high prostate-specific antigen (PSA 10.6ng/ml; 2.5-997.1ng/ml). 3T MRI using a phased-array coil was performed in 171 (MRI group) but not in 498 (non-MRI group) prior to re-biopsy. Transrectal ultrasound-guided biopsy was performed in both MRI and non-MRI groups. MRI and non-MRI groups were compared in terms of cancer detection rate [(number of cancer-proven patients/number of patients in MRI or non-MRI group)×100] and positive core rate [(number of cancer-positive cores/number of cores in MRI or non-MRI group)×100] using Fisher exact test. Odds ratio and 95% confidence interval were also obtained. Pathologic diagnosis of the biopsy was considered standard reference. Results: Of 669 patients, 129 (19.3%) were diagnosed with adenocarcinoma. The cancer detection rates of MRI and non-MRI groups were 33.3% (57/171) and 14.5% (72/498), respectively (p<0.001). The positive core rates of these groups were 9.2% (167/1818) and 3.2% (179/5631), respectively (p<0.001). The odd ratios of cancer detection rate and positive core rate were 3.0 (95% confidence interval 2.0-4.4) and 3.1 (2.5-3.8), respectively. Conclusion: Re-biopsy with preceded MRI yields higher cancer detection rate and positive core rate than re-biopsy without preceded MRI. MRI should be considered prior to re-biopsy in patients with previous negative biopsy and persistently high PSA. Springer Science+Business Media New York, 2014 Park Byung The Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea aut Jeon Seong The Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, 135-710, Seoul, Korea aut Park Bumsoo The Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, 135-710, Seoul, Korea aut Park Jung The Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea aut Kim Chan The Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea aut Lee Hyun The Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, 135-710, Seoul, Korea aut Choi Han The Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, 135-710, Seoul, Korea aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/3(2015-03-01), 571-577 0942-8925 40:3<571 2015 40 261 https://doi.org/10.1007/s00261-014-0245-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0245-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Park Byung The Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Jeon Seong The Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Park Bumsoo The Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Park Jung The Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Chan The Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Hyun The Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Choi Han The Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, 135-710, Seoul, Korea aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/3(2015-03-01), 571-577 0942-8925 40:3<571 2015 40 261