caa a22 4500 605494037 CHVBK 20210128100524.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00261-014-0244-4 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0244-4 Differentiation of lipid poor angiomyolipoma from hepatocellular carcinoma on gadoxetic acid-enhanced liver MR imaging [Elektronische Daten] [Rihyeon Kim, Jeong Lee, Ijin Joo, Dong Lee, Sungmin Woo, Joon Han, Byung Choi] Purpose: To investigate magnetic resonance (MR) findings of angiomyolipoma (AML) on gadoxetic acid-enhanced MR imaging, and to identify features that differentiate AML from hepatocellular carcinoma (HCC) in patients with a low risk of HCC development. Methods: This retrospective study was institutional review board approved, and the requirement for informed consent was waived. Twelve patients with hepatic AML who underwent gadoxetic acid-enhanced MRI with no risk factors for HCC development were recruited. Twenty-seven patients with HCC under the same inclusion criteria were recruited as control. Two radiologists analyzed the images in consensus for morphologic features, enhancement patterns, and hepatobiliary phase (HBP) findings. All results were analyzed using the Mann-Whitney test, two-tailed Fisher exact test, and chi-square test. Results: Patients with AML were younger than those with HCC (48.8±15years for AML vs. 62.7±14.2years for HCC, p=0.008) with female predominance, while most HCC patients were male (75% (9/12) vs. 15% (4/27), p<0.001). The most prevalent enhancement pattern was arterial enhancement followed by hypointensity at portal or transitional phases for both AMLs (58% (7/12)) and HCCs (74% (20/27)) (p=0.455). However, during the HBP, AMLs frequently showed more homogeneous hypointensity than HCCs (83% (10/12) vs. 41% (11/27), p=0.018). When compared with the signal intensity of the spleen, the mean relative signal intensity of the AML was 91.2±15.4%, while in HCCs, it was 128.7±40% (p<0.001). Conclusions: Although AMLs showed similar enhancement patterns to HCCs during the dynamic phases of gadoxetic acid-enhanced MRI, using characteristic MR features of AML during the HBP and demographic differences, one can better differentiate AML from HCC. Springer Science+Business Media New York, 2014 Hepatic angiomyolipoma nationallicence Hepatocellular carcinoma nationallicence Gadoxetic acid-enhanced MR nationallicence Hepatobiliary phase nationallicence Kim Rihyeon Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-Gu, 110-744, Seoul, Korea aut Lee Jeong Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-Gu, 110-744, Seoul, Korea aut Joo Ijin Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-Gu, 110-744, Seoul, Korea aut Lee Dong Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-Gu, 110-744, Seoul, Korea aut Woo Sungmin Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-Gu, 110-744, Seoul, Korea aut Han Joon Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-Gu, 110-744, Seoul, Korea aut Choi Byung Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-Gu, 110-744, Seoul, Korea aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/3(2015-03-01), 531-541 0942-8925 40:3<531 2015 40 261 https://doi.org/10.1007/s00261-014-0244-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0244-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Rihyeon Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-Gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Jeong Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-Gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Joo Ijin Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-Gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Dong Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-Gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Woo Sungmin Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-Gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Han Joon Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-Gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Choi Byung Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-Gu, 110-744, Seoul, Korea aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/3(2015-03-01), 531-541 0942-8925 40:3<531 2015 40 261