caa a22 4500 605494118 CHVBK 20210128100524.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00261-014-0246-2 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0246-2 Comparison of calculated and acquired high b value diffusion-weighted imaging in prostate cancer [Elektronische Daten] [Kinzya Grant, Harsh Agarwal, Joanna Shih, Marcelino Bernardo, Yuxi Pang, Dagane Daar, Maria Merino, Bradford Wood, Peter Pinto, Peter Choyke, Baris Turkbey] Purpose: To determine whether the performance of calculated high b value diffusion-weighted images (DWI) derived from regular lower b value DWI using exponential diffusion decay models (intravoxel incoherent motion=IVIM and diffusional kurtosis=DK) is comparable to acquired high b value DWI in prostate cancer detection. Materials and Methods: One hundred six patients underwent diagnostic multiparametric prostate MRI at 3T using an endorectal coil. Five b value (b=0, 188, 375, 563, 750s/mm2) DWI and high b value (b=0, 1000 and 2000s/mm2) DWI were acquired. Calculated high b value (b=1000s/mm2 and b=2000s/mm2) DWI were derived from the DWI dataset using DK and IVIM models. Calculated and acquired high b value DWI images were compared for lesion visibility and image quality by two experienced radiologists (1 and 6years of experience). GEE with Wald test was used to compare the image quality among the four calculated high b value DWI by comparing the proportion of lesions in each model which were comparable to the acquired images. This comparison was done for all lesions and by lesion location (PZ or CG; low apical/anterior or apical/mid/base) Results: More lesions were visible on acquired b=2000s/mm2 compared to b=1000s/mm2 DWI. Calculated high b value DWI using the IVIM model had approximately the same number of lesions as acquired high b value DWI, whereas the DK model had fewer lesions than acquired images. The image quality of calculated high b value DWI was comparable to that of acquired images, and the highest quality images were obtained with b1000IVIM. The image quality of calculated b1000IVIM was the same as that of acquired DWI in apical/mid/base (98%) locations and comparable in low apical and anterior (95.4%) locations. The image quality of calculated b2000IVIM was inferior in both apical/mid/base (86.2%) locations and comparable in low apical and anterior (83.9%) locations. Conclusion: Calculated high b value DWI obtained using IVIM model has same lesion visibility as that of acquired DWI. The image quality of calculated high b value DWI relative to corresponding acquired DWI decreases with increase in b value. Springer Science+Business Media New York, 2014 Prostate cancer nationallicence MRI nationallicence Diffusion-weighted imaging nationallicence High b value nationallicence Grant Kinzya Molecular Imaging Program, National Cancer Institute (NCI), NIH 10 Center Dr, MSC 1182, Bldg 10, Room B3B85, 20892-1088, Bethesda, MD, USA aut Agarwal Harsh Molecular Imaging Program, National Cancer Institute (NCI), NIH 10 Center Dr, MSC 1182, Bldg 10, Room B3B85, 20892-1088, Bethesda, MD, USA aut Shih Joanna Biometric Research Branch, Division of Cancer Treatment and Diagnosis, NCI, NIH, Bethesda, MD, USA aut Bernardo Marcelino Molecular Imaging Program, National Cancer Institute (NCI), NIH 10 Center Dr, MSC 1182, Bldg 10, Room B3B85, 20892-1088, Bethesda, MD, USA aut Pang Yuxi Philips Healthcare, Cleveland, OH, USA aut Daar Dagane Molecular Imaging Program, National Cancer Institute (NCI), NIH 10 Center Dr, MSC 1182, Bldg 10, Room B3B85, 20892-1088, Bethesda, MD, USA aut Merino Maria Laboratory of Pathology, NCI, NIH, Bethesda, MD, USA aut Wood Bradford Clinical Center, Center for Interventional Oncology, NCI and Radiology and Imaging Sciences, NIH, Bethesda, MD, USA aut Pinto Peter Urologic Oncology Branch, NCI, NIH, Bethesda, MD, USA aut Choyke Peter Molecular Imaging Program, National Cancer Institute (NCI), NIH 10 Center Dr, MSC 1182, Bldg 10, Room B3B85, 20892-1088, Bethesda, MD, USA aut Turkbey Baris Molecular Imaging Program, National Cancer Institute (NCI), NIH 10 Center Dr, MSC 1182, Bldg 10, Room B3B85, 20892-1088, Bethesda, MD, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/3(2015-03-01), 578-586 0942-8925 40:3<578 2015 40 261 https://doi.org/10.1007/s00261-014-0246-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0246-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grant Kinzya Molecular Imaging Program, National Cancer Institute (NCI), NIH 10 Center Dr, MSC 1182, Bldg 10, Room B3B85, 20892-1088, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Agarwal Harsh Molecular Imaging Program, National Cancer Institute (NCI), NIH 10 Center Dr, MSC 1182, Bldg 10, Room B3B85, 20892-1088, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Shih Joanna Biometric Research Branch, Division of Cancer Treatment and Diagnosis, NCI, NIH, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Bernardo Marcelino Molecular Imaging Program, National Cancer Institute (NCI), NIH 10 Center Dr, MSC 1182, Bldg 10, Room B3B85, 20892-1088, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Pang Yuxi Philips Healthcare, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Daar Dagane Molecular Imaging Program, National Cancer Institute (NCI), NIH 10 Center Dr, MSC 1182, Bldg 10, Room B3B85, 20892-1088, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Merino Maria Laboratory of Pathology, NCI, NIH, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Wood Bradford Clinical Center, Center for Interventional Oncology, NCI and Radiology and Imaging Sciences, NIH, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Pinto Peter Urologic Oncology Branch, NCI, NIH, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Choyke Peter Molecular Imaging Program, National Cancer Institute (NCI), NIH 10 Center Dr, MSC 1182, Bldg 10, Room B3B85, 20892-1088, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Turkbey Baris Molecular Imaging Program, National Cancer Institute (NCI), NIH 10 Center Dr, MSC 1182, Bldg 10, Room B3B85, 20892-1088, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/3(2015-03-01), 578-586 0942-8925 40:3<578 2015 40 261