Mass-like peripheral zone enhancement on CT is predictive of higher-grade (Gleason 4+3 and higher) prostate cancer
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| 024 | 7 | 0 | |a 10.1007/s00261-014-0233-7 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-014-0233-7 | ||
| 245 | 0 | 0 | |a Mass-like peripheral zone enhancement on CT is predictive of higher-grade (Gleason 4+3 and higher) prostate cancer |h [Elektronische Daten] |c [D. Glazer, M. Davenport, S. Khalatbari, R. Cohan, J. Ellis, E. Caoili, E. Stein, J. Childress, W. Masch, J. Brown, B. Mollard, J. Montgomery, G. Palapattu, I. Francis] |
| 520 | 3 | |a Purpose: To determine whether focal peripheral zone enhancement on routine venous-phase CT is predictive of higher-grade (Gleason 4+3 and higher) prostate cancer. Materials and methods: IRB approval was obtained and informed consent waived for this HIPAA-compliant retrospective study. Forty-three patients with higher-grade prostate cancer (≥Gleason 4+3) and 96 with histology-confirmed lower-grade (≤Gleason 3+4 [n=47]) or absent (n=49) prostate cancer imaged with venous-phase CT comprised the study population. CT images were reviewed by ten blinded radiologists (5 attendings, 5 residents) who scored peripheral zone enhancement on a scale of 1 (benign) to 5 (malignant). Mass-like peripheral zone enhancement was considered malignant. Likelihood ratios (LR) and specificities were calculated. Multivariate conditional logistic regression analyses were conducted. Results: Scores of "5” were strongly predictive of higher-grade prostate cancer (pooled LR+ 9.6 [95% CI 5.8-15.8]) with rare false positives (pooled specificity: 0.98 [942/960, 95% CI 0.98-0.99]; all 10 readers had specificity ≥95%). Attending scores of "5” were more predictive than resident scores of "5” (LR+: 14.7 [95% CI 5.8-37.2] vs. 7.6 [95% CI 4.2-13.7]) with similar specificity (0.99 [475/480, 95% CI 0.98-1.00] vs. 0.97 [467/480, 95% CI 0.96-0.99]). Significant predictors of an assigned score of "5” included presence of a peripheral zone mass (p<0.0001), larger size (p<0.0001), and less reader experience (p=0.0008). Significant predictors of higher-grade prostate cancer included presence of a peripheral zone mass (p=0.0002) and larger size (p<0.0001). Conclusion: Focal mass-like peripheral zone enhancement on routine venous-phase CT is specific and predictive of higher-grade (Gleason 4+3 and higher) prostate cancer. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a Prostate cancer |2 nationallicence | |
| 690 | 7 | |a CT |2 nationallicence | |
| 690 | 7 | |a Peripheral zone |2 nationallicence | |
| 690 | 7 | |a Repeatability |2 nationallicence | |
| 690 | 7 | |a Likelihood ratio |2 nationallicence | |
| 700 | 1 | |a Glazer |D D. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | |
| 700 | 1 | |a Davenport |D M. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | |
| 700 | 1 | |a Khalatbari |D S. |u Michigan Institute for Clinical and Health Research, Ann Arbor, MI, USA |4 aut | |
| 700 | 1 | |a Cohan |D R. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | |
| 700 | 1 | |a Ellis |D J. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | |
| 700 | 1 | |a Caoili |D E. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | |
| 700 | 1 | |a Stein |D E. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | |
| 700 | 1 | |a Childress |D J. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | |
| 700 | 1 | |a Masch |D W. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | |
| 700 | 1 | |a Brown |D J. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | |
| 700 | 1 | |a Mollard |D B. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | |
| 700 | 1 | |a Montgomery |D J. |u Department of Urology, University of Michigan Health System, Ann Arbor, MI, USA |4 aut | |
| 700 | 1 | |a Palapattu |D G. |u Department of Urology, University of Michigan Health System, Ann Arbor, MI, USA |4 aut | |
| 700 | 1 | |a Francis |D I. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/3(2015-03-01), 560-570 |x 0942-8925 |q 40:3<560 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-014-0233-7 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-014-0233-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Glazer |D D. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Davenport |D M. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Khalatbari |D S. |u Michigan Institute for Clinical and Health Research, Ann Arbor, MI, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cohan |D R. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ellis |D J. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Caoili |D E. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Stein |D E. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Childress |D J. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Masch |D W. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Brown |D J. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mollard |D B. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Montgomery |D J. |u Department of Urology, University of Michigan Health System, Ann Arbor, MI, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Palapattu |D G. |u Department of Urology, University of Michigan Health System, Ann Arbor, MI, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Francis |D I. |u Department of Radiology, University of Michigan Health System, B2-A209P, 48109, Ann Arbor, MI, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/3(2015-03-01), 560-570 |x 0942-8925 |q 40:3<560 |1 2015 |2 40 |o 261 | ||