Inter- and intra-individual comparative study of two gadolinium-based agents: A pilot study
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| 024 | 7 | 0 | |a 10.1007/s00261-014-0248-0 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-014-0248-0 | ||
| 245 | 0 | 0 | |a Inter- and intra-individual comparative study of two gadolinium-based agents: A pilot study |h [Elektronische Daten] |c [Kyung Shin, Mamdoh AlObaidy, Miguel Ramalho, Yong Jeon, Lauren Burke, Ersan Altun, Clifton Stallings, Richard Semelka] |
| 520 | 3 | |a Purpose: The aim of the study was to evaluate the acute adverse events rate and enhancement properties of gadoterate meglumine (Dotarem®) and gadobenate dimeglumine (MultiHance®) in a small-scale controlled double-blinded study, using inter- and intra-individual comparisons. Materials and Methods: Forty-one randomly selected patients were scanned with Dotarem®. The rate of adverse reactions, qualitative and quantitative image evaluation was performed vs. a control group of 46 patients who underwent MultiHance® over the same 1-month time period (population 1), and 27 patients who underwent both Dotarem® and MultiHance®-enhanced body MRI studies within an 18-month period (population 2). Data were subjected to statistical analysis. Results: Only 1 mild acute adverse event (vomiting) was observed in population 1 (with Dotarem®). Blinded assessment of image quality was good for both agents in all patients. Population 1 showed significantly higher liver percentage enhancement with MultiHance® (p<0.0001). There was a trend to higher pancreas-to-liver enhancement with Dotarem®, significant in population 2 (p=0.0333). Conclusion: This small-scale multi-blinded study characterizes a strategy to objectively assess intravenous contrast agents, which may be an ideal method to evaluate whether a new contrast agent should be introduced for clinical use at any institution, and to re-evaluate the agent in standard use. Whenever available, intra-individual assessment may be ideal. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a Gadolinium |2 nationallicence | |
| 690 | 7 | |a Gadoterate meglumine |2 nationallicence | |
| 690 | 7 | |a Gadobenate dimeglumine |2 nationallicence | |
| 690 | 7 | |a Dotarem® |2 nationallicence | |
| 690 | 7 | |a MultiHance® |2 nationallicence | |
| 690 | 7 | |a Proof of concept |2 nationallicence | |
| 700 | 1 | |a Shin |D Kyung |u Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA |4 aut | |
| 700 | 1 | |a AlObaidy |D Mamdoh |u Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA |4 aut | |
| 700 | 1 | |a Ramalho |D Miguel |u Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA |4 aut | |
| 700 | 1 | |a Jeon |D Yong |u Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA |4 aut | |
| 700 | 1 | |a Burke |D Lauren |u Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA |4 aut | |
| 700 | 1 | |a Altun |D Ersan |u Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA |4 aut | |
| 700 | 1 | |a Stallings |D Clifton |u Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA |4 aut | |
| 700 | 1 | |a Semelka |D Richard |u Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/4(2015-04-01), 865-874 |x 0942-8925 |q 40:4<865 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-014-0248-0 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-014-0248-0 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shin |D Kyung |u Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a AlObaidy |D Mamdoh |u Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ramalho |D Miguel |u Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jeon |D Yong |u Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Burke |D Lauren |u Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Altun |D Ersan |u Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Stallings |D Clifton |u Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Semelka |D Richard |u Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/4(2015-04-01), 865-874 |x 0942-8925 |q 40:4<865 |1 2015 |2 40 |o 261 | ||