caa a22 4500 605494134 CHVBK 20210128100524.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00261-014-0248-0 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0248-0 Inter- and intra-individual comparative study of two gadolinium-based agents: A pilot study [Elektronische Daten] [Kyung Shin, Mamdoh AlObaidy, Miguel Ramalho, Yong Jeon, Lauren Burke, Ersan Altun, Clifton Stallings, Richard Semelka] Purpose: The aim of the study was to evaluate the acute adverse events rate and enhancement properties of gadoterate meglumine (Dotarem®) and gadobenate dimeglumine (MultiHance®) in a small-scale controlled double-blinded study, using inter- and intra-individual comparisons. Materials and Methods: Forty-one randomly selected patients were scanned with Dotarem®. The rate of adverse reactions, qualitative and quantitative image evaluation was performed vs. a control group of 46 patients who underwent MultiHance® over the same 1-month time period (population 1), and 27 patients who underwent both Dotarem® and MultiHance®-enhanced body MRI studies within an 18-month period (population 2). Data were subjected to statistical analysis. Results: Only 1 mild acute adverse event (vomiting) was observed in population 1 (with Dotarem®). Blinded assessment of image quality was good for both agents in all patients. Population 1 showed significantly higher liver percentage enhancement with MultiHance® (p<0.0001). There was a trend to higher pancreas-to-liver enhancement with Dotarem®, significant in population 2 (p=0.0333). Conclusion: This small-scale multi-blinded study characterizes a strategy to objectively assess intravenous contrast agents, which may be an ideal method to evaluate whether a new contrast agent should be introduced for clinical use at any institution, and to re-evaluate the agent in standard use. Whenever available, intra-individual assessment may be ideal. Springer Science+Business Media New York, 2014 Gadolinium nationallicence Gadoterate meglumine nationallicence Gadobenate dimeglumine nationallicence Dotarem® nationallicence MultiHance® nationallicence Proof of concept nationallicence Shin Kyung Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA aut AlObaidy Mamdoh Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA aut Ramalho Miguel Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA aut Jeon Yong Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA aut Burke Lauren Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA aut Altun Ersan Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA aut Stallings Clifton Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA aut Semelka Richard Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 865-874 0942-8925 40:4<865 2015 40 261 https://doi.org/10.1007/s00261-014-0248-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0248-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shin Kyung Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- AlObaidy Mamdoh Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Ramalho Miguel Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Jeon Yong Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Burke Lauren Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Altun Ersan Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Stallings Clifton Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Semelka Richard Department of Radiology, University of North Carolina at Chapel Hill, 2022 Old Clinic Bldg., CB 7510, 27599-7510, Chapel Hill, NC, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 865-874 0942-8925 40:4<865 2015 40 261