caa a22 4500 605494142 CHVBK 20210128100524.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00261-014-0321-8 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0321-8 Magnetic resonance elastography (MRE) in assessing hepatic fibrosis: performance in a cohort of patients with histological data [Elektronische Daten] [Mashal Batheja, Hugo Vargas, Annelise Silva, Forrest Walker, Yu-Hui Chang, Giovanni De Petris, Alvin Silva] Purpose: The purpose of this study was to compare fibrosis seen on liver biopsy to MR elastography (MRE) stiffness measurements in normal controls and patients with abnormal transaminases and chronic liver disease. Methods: The control group consisted of 22 healthy liver transplant donors who by definition had normal transaminases. The patient group (32 patients) was recruited from the Mayo Clinic Arizona hepatobiliary clinic over a 3-year span. All subjects underwent a liver biopsy as part of their evaluation and agreed to MRE within 35days of biopsy. Non-parametric tests were used to compare the MRE-predicted liver fibrosis to the fibrosis noted on liver biopsy. Results: Analysis included 54 subjects (32 patients with chronic liver disease and 22 healthy liver donor candidates). MRE median liver stiffness measurements increased per histologic liver fibrosis stage (one-way ANOVA p=0.001), with significant correlation between increasing fibrosis stage and stiffness values. Median MRE for control group (2.13kPa; mean=2.3±0.6kPa) was significantly lower than for patient group (3.7kPa; mean=4.1±2.1kPa) (p=0.003). Significantly, lower median stiffness was seen in zero-to-moderate (F0-2, n=22) vs. severe fibrosis stages (F3-4, n=10) 2.80 vs. 5.9kPa, respectively (p<0.05). Using a 3.7-kPa cut-off value, the predicted sensitivity and specificity for detecting F0-2 from F3-4 were 91% and 80%, respectively. Conclusions: Our analysis supports previous findings that MRE is a non-invasive and effective method for detection and assessment of liver fibrosis, particularly for discrimination between F0-2 stages and F3-4 stages. MRE may represent a valuable tool to finely discern hepatic fibrosis non-invasively. Springer Science+Business Media New York, 2014 Liver stiffness nationallicence Fibrosis nationallicence Cirrhosis nationallicence Magnetic resonance elastography nationallicence Batheja Mashal Department of Gastroenterology, Mayo Clinic in Arizona, Scottsdale, AZ, USA aut Vargas Hugo Department of Hepatology, Mayo Clinic in Arizona, Scottsdale, AZ, USA aut Silva Annelise Arizona State University, Tempe, AZ, USA aut Walker Forrest Department of Radiology, Mayo Clinic in Arizona, 13400 East Shea Boulevard, 85259, Scottsdale, AZ, USA aut Chang Yu-Hui Division of Health Science Research, Mayo Clinic in Arizona, Scottsdale, AZ, USA aut De Petris Giovanni Department of Laboratory Medicine/Pathology, Mayo Clinic in Arizona, Scottsdale, AZ, USA aut Silva Alvin Department of Radiology, Mayo Clinic in Arizona, 13400 East Shea Boulevard, 85259, Scottsdale, AZ, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 760-765 0942-8925 40:4<760 2015 40 261 https://doi.org/10.1007/s00261-014-0321-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0321-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Batheja Mashal Department of Gastroenterology, Mayo Clinic in Arizona, Scottsdale, AZ, USA aut NATIONALLICENCE 700 1- Vargas Hugo Department of Hepatology, Mayo Clinic in Arizona, Scottsdale, AZ, USA aut NATIONALLICENCE 700 1- Silva Annelise Arizona State University, Tempe, AZ, USA aut NATIONALLICENCE 700 1- Walker Forrest Department of Radiology, Mayo Clinic in Arizona, 13400 East Shea Boulevard, 85259, Scottsdale, AZ, USA aut NATIONALLICENCE 700 1- Chang Yu-Hui Division of Health Science Research, Mayo Clinic in Arizona, Scottsdale, AZ, USA aut NATIONALLICENCE 700 1- De Petris Giovanni Department of Laboratory Medicine/Pathology, Mayo Clinic in Arizona, Scottsdale, AZ, USA aut NATIONALLICENCE 700 1- Silva Alvin Department of Radiology, Mayo Clinic in Arizona, 13400 East Shea Boulevard, 85259, Scottsdale, AZ, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 760-765 0942-8925 40:4<760 2015 40 261