caa a22 4500 605494150 CHVBK 20210128100524.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00261-015-0347-6 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0347-6 Non-invasive detection of liver fibrosis: MR imaging features vs. MR elastography [Elektronische Daten] [Sudhakar Venkatesh, Meng Yin, Naoki Takahashi, James Glockner, Jayant Talwalkar, Richard Ehman] Purpose: To compare accuracy of morphological features of liver on MRI and liver stiffness with MR elastography (MRE) for detection of significant liver fibrosis and cirrhosis. Materials and methods: In this retrospective study, we evaluated 62 patients who underwent liver MRI with MRE and histological confirmation of liver fibrosis within 6months. Two radiologists, blinded to histology results, independently evaluated liver parenchyma texture, surface nodularity, signs of volumetric changes, and portal hypertension for presence of significant fibrosis and cirrhosis. Two more readers independently calculated mean liver stiffness values with MRE. Interobserver agreement was evaluated with kappa and intra-class correlation coefficient (ICC) analysis. Diagnostic accuracy was assessed with area under receiver operating characteristic (AUROC) analysis. Comparison of AUROCs of MRI and MRE was performed. Results: Liver fibrosis was present in 37 patients. The interobserver agreement was poor to good (κ=0.12-0.74) for MRI features and excellent for MRE (ICC 0.97, 95% CI 0.95-0.98). MRI features had 48.5%-87.9% sensitivity, 55.2%-100% specificity, and 71.5%-81.6% accuracy/for detection of significant fibrosis. MRE performed better with 100% sensitivity, 96.5% specificity, and 98.9% accuracy. For the detection of cirrhosis, MRE performed better than MRI features with 88.2% sensitivity (vs. 41.2%-82.3%), 91.1% specificity (vs. 64.4%-95.6%), and 93.5% accuracy (vs. 60.6%-80.5%). Among the MRI features, surface nodularity and overall impression had the best accuracies of 80.3% and 81.6% for detection of significant fibrosis, respectively. For cirrhosis, parenchyma texture and overall impression had the best accuracies of 80.5% and 79.7%, respectively. Overall, MRE had significantly greater AUROC than MRI features for detection of both significant fibrosis (0.98.9 vs 0.71-0.82, P<0.001) and cirrhosis (0.93.5 vs. 0.61-0.80.5, P<0.01). Conclusion: MRE is superior to MRI for the non-invasive diagnosis of significant liver fibrosis and cirrhosis. Springer Science+Business Media New York, 2015 Liver fibrosis nationallicence Cirrhosis nationallicence Magnetic resonance elastography nationallicence Liver morphology nationallicence Parenchyma texture nationallicence Signs of cirrhosis nationallicence Venkatesh Sudhakar Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Yin Meng Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Takahashi Naoki Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Glockner James Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Talwalkar Jayant Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA aut Ehman Richard Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 766-775 0942-8925 40:4<766 2015 40 261 https://doi.org/10.1007/s00261-015-0347-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0347-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Venkatesh Sudhakar Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Yin Meng Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Takahashi Naoki Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Glockner James Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Talwalkar Jayant Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Ehman Richard Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 766-775 0942-8925 40:4<766 2015 40 261