caa a22 4500 605494207 CHVBK 20210128100524.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00261-015-0372-5 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0372-5 Magnetic resonance elastography: evaluation of new inversion algorithm and quantitative analysis method [Elektronische Daten] [Annelise Silva, Roger Grimm, Kevin Glaser, Yinlin Fu, Teresa Wu, Richard Ehman, Alvin Silva] Purpose: To assess mean shear hepatic stiffness calculations using various region of interest (ROI) techniques, a new inversion algorithm, and a confidence threshold mask. Methods: Seventy-three patients (49 with abnormal liver function tests/known chronic liver disease and 24 healthy liver transplant donors) underwent liver biopsy and magnetic resonance elastography (MRE). MRE data processed with the current inversion algorithm [multiscale direct inversion (MSDI)] was assessed using 2 ROI methods (single vs. triple). The data were then reprocessed using the new inversion algorithm (multimodel direct inversion [MMDI]) Hepatic stiffness calculations were performed using a single (70%) ROI method, with/without a 95% confidence threshold mask, and compared with MSDI. Results: For MSDI, average stiffness difference between single and triple ROI methods was not statistically significant by the 2-sample t test [0.15 kilopascals (kPa); P=.77]. For the 2 algorithms, there was little difference in average stiffness measurements of MSDI and MMDI (mean, 0.32kPa; 9%) using a confidence mask with good agreement [intraclass correlation coefficient (ICC), 0.986 (95% CI 0.975-0.994)]. Use of the confidence mask showed excellent consistency and less variance [ICC, 0.995 (95% CI 0.993-0.998)] compared to either the inter-observer or intra-observer freehand technique. Conclusion: MRE analysis showed no significant difference between the 2 freehand ROI techniques. With a 9% average kPa variance, stiffness measurements for MSDI and MMDI were also not significantly different. The use of the confidence mask reduces calculated stiffness variability, which impacts the use of MRE for assessing therapy response and initial/longitudinal assessment of chronic liver disease. Springer Science+Business Media New York, 2015 Cirrhosis nationallicence Liver donor nationallicence Liver elastography nationallicence Magnetic resonance elastography nationallicence Magnetic resonance imaging nationallicence ICC : Intraclass correlation coefficient nationallicence kPA : Kilopascals nationallicence MMDI : Multimodel direct inversion nationallicence MRE : Magnetic resonance elastography nationallicence MSDI : Multiscale direct inversion nationallicence ROI : Region of interest nationallicence Silva Annelise Barrett, The Honors College, Arizona State University, Tempe, AZ, USA aut Grimm Roger Department of Radiology, Mayo Clinic, Rochester, MN, USA aut Glaser Kevin Department of Radiology, Mayo Clinic, Rochester, MN, USA aut Fu Yinlin School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, AZ, USA aut Wu Teresa School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, AZ, USA aut Ehman Richard Department of Radiology, Mayo Clinic, Rochester, MN, USA aut Silva Alvin Department of Radiology, Mayo Clinic, 13400 E Shea Blvd, 85259, Scottsdale, AZ, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 810-817 0942-8925 40:4<810 2015 40 261 https://doi.org/10.1007/s00261-015-0372-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0372-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Silva Annelise Barrett, The Honors College, Arizona State University, Tempe, AZ, USA aut NATIONALLICENCE 700 1- Grimm Roger Department of Radiology, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Glaser Kevin Department of Radiology, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Fu Yinlin School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, AZ, USA aut NATIONALLICENCE 700 1- Wu Teresa School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, AZ, USA aut NATIONALLICENCE 700 1- Ehman Richard Department of Radiology, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Silva Alvin Department of Radiology, Mayo Clinic, 13400 E Shea Blvd, 85259, Scottsdale, AZ, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 810-817 0942-8925 40:4<810 2015 40 261