caa a22 4500 605494215 CHVBK 20210128100525.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00261-014-0310-y doi (NATIONALLICENCE)springer-10.1007/s00261-014-0310-y Magnetic resonance elastography can discriminate normal vs. abnormal liver biopsy in candidates for live liver donation [Elektronische Daten] [Juan Gallegos-Orozco, Alvin Silva, Mashal Batheja, Yu-Hui Chang, Kathleen Hansen, Dora Lam-Himlin, Giovanni De Petris, Bashar Aqel, Thomas Byrne, Elizabeth Carey, David Douglas, David Mulligan, Annelise Silva, Jorge Rakela, Hugo Vargas] Purpose: The aim of this study was to define liver shear stiffness by magnetic resonance elastography (MRE) that distinguishes normal from abnormal liver biopsy, especially when steatosis≥20%, among potential live liver donors. Methods: Baseline clinical, laboratory, imaging, MRE, and liver biopsy results were recorded. Using MRE, hepatic shear stiffness in kilopascals (kPa) was measured and compared to liver biopsy. Comparison between groups was done using χ 2 or Fisher's exact test for categorical variables and Wilcoxon test for continuous variables. Receiver operating characteristic (ROC) curve was calculated to assess diagnostic accuracy. Statistical significance was set at p<0.05. Results: 38 healthy adults were included. Liver biopsy was normal in 27 and abnormal in 11. ROC curve for MRE defined optimal cutoff at 2.6kPa (sensitivity 0.72, specificity 0.85, AUC 0.81) to distinguish these 2 groups. Hepatic steatosis≥20% on biopsy is a contraindication for liver donation in our center. We evaluated the ability of MRE to distinguish this degree of steatosis: 8 persons had steatosis≥20% and were excluded from donation. ROC curve for MRE defined optimal cutoff at 2.82kPa (sensitivity 0.88, specificity 1, AUC 0.98) to identify this group. Conclusions: Liver stiffness measured by MRE, even in the absence of liver fibrosis, can be useful in differentiating normal from abnormal liver histology, and most importantly in patients under evaluation for live liver donation, can very accurately distinguish those with complicated hepatic steatosis≥20%, our cutoff for donation. In the future, MRE might provide supplementary information to make liver biopsy unnecessary in the donor evaluation process. Springer Science+Business Media New York, 2014 Live liver donation nationallicence Elastography nationallicence Liver stiffness nationallicence Liver steatosis nationallicence Live donor liver transplantation nationallicence Gallegos-Orozco Juan Division of Gastroenterology, Hepatology and Nutrition, University of Utah School of Medicine, 30 North 1900 East, SOM 4R118, 84132, Salt Lake City, UT, USA aut Silva Alvin Department of Radiology, Mayo Clinic Arizona, Phoenix, AZ, USA aut Batheja Mashal Division of Gastroenterology, "Carl T. Hayden” VA Medical Center, Phoenix, AZ, USA aut Chang Yu-Hui Department of Biostatistics, Mayo Clinic Arizona, Phoenix, AZ, USA aut Hansen Kathleen Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Phoenix, AZ, USA aut Lam-Himlin Dora Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Phoenix, AZ, USA aut De Petris Giovanni Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Phoenix, AZ, USA aut Aqel Bashar Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Phoenix, AZ, USA aut Byrne Thomas Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Phoenix, AZ, USA aut Carey Elizabeth Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Phoenix, AZ, USA aut Douglas David Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Phoenix, AZ, USA aut Mulligan David Department of Surgery, Yale School of Medicine, New Haven, CT, USA aut Silva Annelise Arizona State University, Tempe, AZ, USA aut Rakela Jorge Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Phoenix, AZ, USA aut Vargas Hugo Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Phoenix, AZ, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 795-802 0942-8925 40:4<795 2015 40 261 https://doi.org/10.1007/s00261-014-0310-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0310-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gallegos-Orozco Juan Division of Gastroenterology, Hepatology and Nutrition, University of Utah School of Medicine, 30 North 1900 East, SOM 4R118, 84132, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- Silva Alvin Department of Radiology, Mayo Clinic Arizona, Phoenix, AZ, USA aut NATIONALLICENCE 700 1- Batheja Mashal Division of Gastroenterology, "Carl T. Hayden” VA Medical Center, Phoenix, AZ, USA aut NATIONALLICENCE 700 1- Chang Yu-Hui Department of Biostatistics, Mayo Clinic Arizona, Phoenix, AZ, USA aut NATIONALLICENCE 700 1- Hansen Kathleen Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Phoenix, AZ, USA aut NATIONALLICENCE 700 1- Lam-Himlin Dora Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Phoenix, AZ, USA aut NATIONALLICENCE 700 1- De Petris Giovanni Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Phoenix, AZ, USA aut NATIONALLICENCE 700 1- Aqel Bashar Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Phoenix, AZ, USA aut NATIONALLICENCE 700 1- Byrne Thomas Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Phoenix, AZ, USA aut NATIONALLICENCE 700 1- Carey Elizabeth Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Phoenix, AZ, USA aut NATIONALLICENCE 700 1- Douglas David Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Phoenix, AZ, USA aut NATIONALLICENCE 700 1- Mulligan David Department of Surgery, Yale School of Medicine, New Haven, CT, USA aut NATIONALLICENCE 700 1- Silva Annelise Arizona State University, Tempe, AZ, USA aut NATIONALLICENCE 700 1- Rakela Jorge Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Phoenix, AZ, USA aut NATIONALLICENCE 700 1- Vargas Hugo Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Phoenix, AZ, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 795-802 0942-8925 40:4<795 2015 40 261