caa a22 4500 60549424X CHVBK 20210128100525.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00261-014-0306-7 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0306-7 Acoustic radiation force impulse quantification of spleen elasticity for assessing liver fibrosis [Elektronische Daten] [Paolo Cabassa, Marco Ravanelli, Angelo Rossini, Gianbattista Contessi, Raed Almajdalawi, Roberto Maroldi] Purpose: The purpose of this study is to assess the correlation between liver fibrosis and spleen stiffness measured by ARFI in patients with chronic viral hepatitis (B or C) and to explore the possible complementary role of spleen and liver ARFI in grading liver fibrosis. Methods: 84 subjects (51 patients, 33 healthy volunteers) were enrolled. ARFI of the spleen and the liver was performed. Patients subsequently underwent liver biopsy for grading liver fibrosis according to Knodell scoring system. Multivariate logistic regression and decision tree analysis were adopted to test the relationship between spleen and liver stiffness (independent variables) and liver fibrosis (F1< vs. ≥F3). Leave-One-Out Cross-Validation was used for validating the predictive classification models. Area under the ROC curve (AUROCC) was used as accuracy metric. Results: Spleen ARFI was able to discriminate early (F1) from severe (≥F3) liver fibrosis with an optimal cut-off of 3.05m/s: AUROCC 0.807, cross-validated AUROCC 0.614. Liver ARFI was superior to spleen ARFI, using a cut-off of 2.11 m/s: AUROCC 0.879, cross-validated AUROCC 0.672. Neither spleen nor liver ARFI was able to differentiate healthy volunteers from F1 patients. Odds ratios derived from logistic regression were 23.1 and 9.9 for liver and spleen ARFI, respectively; resulting AUROCC was 0.905 (cross-validated 0.848). A decision tree considering the sequential use of liver and spleen ARFI with cut-off of 2.14 and 3.39m/s, respectively, resulted in AUROCC of 0.903 (cross-validated 0.7). Conclusions: Spleen ARFI has the potential to discriminate early from severe liver fibrosis. Spleen and liver ARFI, when combined, show a better discriminative power than liver ARFI alone. Springer Science+Business Media New York, 2014 Spleen/ultrasonography nationallicence Elasticity imaging techniques nationallicence Liver fibrosis nationallicence Ultrasonography nationallicence Spleen stiffness nationallicence Liver stiffness nationallicence Cabassa Paolo Department of Radiology, University of Brescia, Piazzale Spedali Civili 1, 25123, Brescia, Italy aut Ravanelli Marco Department of Radiology, University of Brescia, Piazzale Spedali Civili 1, 25123, Brescia, Italy aut Rossini Angelo Department of Hepatology, Spedali Civili Brescia, 25123, Brescia, Italy aut Contessi Gianbattista Department of Hepatology, Spedali Civili Brescia, 25123, Brescia, Italy aut Almajdalawi Raed Department of Radiology, University of Brescia, Piazzale Spedali Civili 1, 25123, Brescia, Italy aut Maroldi Roberto Department of Radiology, University of Brescia, Piazzale Spedali Civili 1, 25123, Brescia, Italy aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 738-744 0942-8925 40:4<738 2015 40 261 https://doi.org/10.1007/s00261-014-0306-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0306-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cabassa Paolo Department of Radiology, University of Brescia, Piazzale Spedali Civili 1, 25123, Brescia, Italy aut NATIONALLICENCE 700 1- Ravanelli Marco Department of Radiology, University of Brescia, Piazzale Spedali Civili 1, 25123, Brescia, Italy aut NATIONALLICENCE 700 1- Rossini Angelo Department of Hepatology, Spedali Civili Brescia, 25123, Brescia, Italy aut NATIONALLICENCE 700 1- Contessi Gianbattista Department of Hepatology, Spedali Civili Brescia, 25123, Brescia, Italy aut NATIONALLICENCE 700 1- Almajdalawi Raed Department of Radiology, University of Brescia, Piazzale Spedali Civili 1, 25123, Brescia, Italy aut NATIONALLICENCE 700 1- Maroldi Roberto Department of Radiology, University of Brescia, Piazzale Spedali Civili 1, 25123, Brescia, Italy aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 738-744 0942-8925 40:4<738 2015 40 261