Whole-organ and segmental stiffness measured with liver magnetic resonance elastography in healthy adults: significance of the region of interest
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| 024 | 7 | 0 | |a 10.1007/s00261-014-0278-7 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-014-0278-7 | ||
| 245 | 0 | 0 | |a Whole-organ and segmental stiffness measured with liver magnetic resonance elastography in healthy adults: significance of the region of interest |h [Elektronische Daten] |c [Grażyna Rusak, Elżbieta Zawada, Adam Lemanowicz, Zbigniew Serafin] |
| 520 | 3 | |a Purpose: MR elastography (MRE) is a recent non-invasive technique that provides in vivo data on the viscoelasticity of the liver. Since the method is not well established, several different protocols were proposed that differ in results. The aim of the study was to analyze the variability of stiffness measurements in different regions of the liver. Methods: Twenty healthy adults aged 24-45years were recruited. The examination was performed using a mechanical excitation of 64Hz. MRE images were fused with axial T2WI breath-hold images (thickness 10mm, spacing 10mm). Stiffness was measured as a mean value of each cross section of the whole liver, on a single largest cross section, in the right lobe, and in ROIs (50 pix.) placed in the center of the left lobe, segments 5/6, 7, 8, and the parahilar region. Results: Whole-liver stiffness ranged from 1.56 to 2.75kPa. Mean segmental stiffness differed significantly between the tested regions (range from 1.55±0.28 to 2.37±0.32kPa; P<0.0001, ANOVA). Within-method variability of measurements ranged from 14% for whole liver and segment 8-26% for segment 7. Within-subject variability ranged from 13 to 31%. Results of measurement within segment 8 were closest to the whole-liver method (ICC, 0.84). Conclusions: Stiffness of the liver presented significant variability depending on the region of measurement. The most reproducible method is averaging of cross sections of the whole liver. There was significant variability between stiffness in subjects considered healthy, which requires further investigation. | |
| 540 | |a The Author(s), 2014 | ||
| 690 | 7 | |a Liver |2 nationallicence | |
| 690 | 7 | |a Stiffness |2 nationallicence | |
| 690 | 7 | |a MR elastography |2 nationallicence | |
| 690 | 7 | |a Variability |2 nationallicence | |
| 700 | 1 | |a Rusak |D Grażyna |u Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland |4 aut | |
| 700 | 1 | |a Zawada |D Elżbieta |u Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland |4 aut | |
| 700 | 1 | |a Lemanowicz |D Adam |u Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland |4 aut | |
| 700 | 1 | |a Serafin |D Zbigniew |u Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/4(2015-04-01), 776-782 |x 0942-8925 |q 40:4<776 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-014-0278-7 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-014-0278-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rusak |D Grażyna |u Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zawada |D Elżbieta |u Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lemanowicz |D Adam |u Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Serafin |D Zbigniew |u Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/4(2015-04-01), 776-782 |x 0942-8925 |q 40:4<776 |1 2015 |2 40 |o 261 | ||