caa a22 4500 605494274 CHVBK 20210128100525.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00261-014-0278-7 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0278-7 Whole-organ and segmental stiffness measured with liver magnetic resonance elastography in healthy adults: significance of the region of interest [Elektronische Daten] [Grażyna Rusak, Elżbieta Zawada, Adam Lemanowicz, Zbigniew Serafin] Purpose: MR elastography (MRE) is a recent non-invasive technique that provides in vivo data on the viscoelasticity of the liver. Since the method is not well established, several different protocols were proposed that differ in results. The aim of the study was to analyze the variability of stiffness measurements in different regions of the liver. Methods: Twenty healthy adults aged 24-45years were recruited. The examination was performed using a mechanical excitation of 64Hz. MRE images were fused with axial T2WI breath-hold images (thickness 10mm, spacing 10mm). Stiffness was measured as a mean value of each cross section of the whole liver, on a single largest cross section, in the right lobe, and in ROIs (50 pix.) placed in the center of the left lobe, segments 5/6, 7, 8, and the parahilar region. Results: Whole-liver stiffness ranged from 1.56 to 2.75kPa. Mean segmental stiffness differed significantly between the tested regions (range from 1.55±0.28 to 2.37±0.32kPa; P<0.0001, ANOVA). Within-method variability of measurements ranged from 14% for whole liver and segment 8-26% for segment 7. Within-subject variability ranged from 13 to 31%. Results of measurement within segment 8 were closest to the whole-liver method (ICC, 0.84). Conclusions: Stiffness of the liver presented significant variability depending on the region of measurement. The most reproducible method is averaging of cross sections of the whole liver. There was significant variability between stiffness in subjects considered healthy, which requires further investigation. The Author(s), 2014 Liver nationallicence Stiffness nationallicence MR elastography nationallicence Variability nationallicence Rusak Grażyna Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland aut Zawada Elżbieta Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland aut Lemanowicz Adam Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland aut Serafin Zbigniew Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 776-782 0942-8925 40:4<776 2015 40 261 https://doi.org/10.1007/s00261-014-0278-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0278-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rusak Grażyna Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland aut NATIONALLICENCE 700 1- Zawada Elżbieta Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland aut NATIONALLICENCE 700 1- Lemanowicz Adam Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland aut NATIONALLICENCE 700 1- Serafin Zbigniew Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 776-782 0942-8925 40:4<776 2015 40 261