caa a22 4500 605494312 CHVBK 20210128100525.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00261-014-0154-5 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0154-5 Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease using acoustic radiation force impulse elastography [Elektronische Daten] [Dakun Zhang, Peng Li, Min Chen, Liping Liu, Yang Liu, Yuanyuan Zhao, Ruifang Wang] Objectives: To investigate the diagnostic performance of the acoustic radiation force impulse (ARFI) elastography for the assessment of the liver fibrosis in alcoholic liver disease (ALD). Methods: We included 112 patients with ALD in whom liver biopsy, ARFI elastography, and aspartate-to-platelet ratio index (APRI) measurements were performed. Results: ARFI elastography correlated significantly with histological fibrosis (r=0.685, P<0.001) in patients with ALD. The diagnostic accuracies expressed as areas under receiver operating characteristic (AUROC) curves for ARFI elastography and APRI were 0.846 and 0.763 for the diagnosis of significant fibrosis (S≥2), 0.875 and 0.688 for the diagnosis of severe fibrosis (S≥3), and 0.893 and 0.648 for the diagnosis of liver cirrhosis, respectively. The AUROC values of ARFI elastography were significantly better than those of APRI for predicting severe fibrosis (P=0.02) and cirrhosis (P=0.04). The optimum cutoff values for ARFI elastography were 1.33m/s for S≥2, 1.40m/s for S≥3, and 1.65m/s for S=4 in patients with elevated alanine aminotransferase (ALT) levels; these decreased to 1.24m/s for S≥2, 1.27m/s for S≥3, and 1.41m/s for S=4 in patients with normal ALT. Conclusion: ARFI elastography is an acceptable method for predicting the severity of fibrosis in patients with ALD. ARFI elastography is influenced by elevated aminotransferase levels in ALD. Springer Science+Business Media New York, 2014 Acoustic radiation force impulse elastography nationallicence Alcoholic liver disease nationallicence Cirrhosis nationallicence Liver fibrosis nationallicence Zhang Dakun Department of Ultrasound, The 302 Hospital of PLA, No. 100, Xi Si Huan Zhong Lu, 100039, Beijing, China aut Li Peng Second Clinic Department, Peking University School of Stomatology, 100101, Beijing, China aut Chen Min Department of Ultrasound, The 302 Hospital of PLA, No. 100, Xi Si Huan Zhong Lu, 100039, Beijing, China aut Liu Liping Department of Ultrasound, The First Hospital Affiliated to Shanxi Medical University, 030001, Taiyuan, China aut Liu Yang Department of Ultrasound, The 302 Hospital of PLA, No. 100, Xi Si Huan Zhong Lu, 100039, Beijing, China aut Zhao Yuanyuan Department of Ultrasound, Qi Lu Hospital (Qing dao), Shandong University, 266000, Qingdao, China aut Wang Ruifang Department of Ultrasound, The 302 Hospital of PLA, No. 100, Xi Si Huan Zhong Lu, 100039, Beijing, China aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 723-729 0942-8925 40:4<723 2015 40 261 https://doi.org/10.1007/s00261-014-0154-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0154-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang Dakun Department of Ultrasound, The 302 Hospital of PLA, No. 100, Xi Si Huan Zhong Lu, 100039, Beijing, China aut NATIONALLICENCE 700 1- Li Peng Second Clinic Department, Peking University School of Stomatology, 100101, Beijing, China aut NATIONALLICENCE 700 1- Chen Min Department of Ultrasound, The 302 Hospital of PLA, No. 100, Xi Si Huan Zhong Lu, 100039, Beijing, China aut NATIONALLICENCE 700 1- Liu Liping Department of Ultrasound, The First Hospital Affiliated to Shanxi Medical University, 030001, Taiyuan, China aut NATIONALLICENCE 700 1- Liu Yang Department of Ultrasound, The 302 Hospital of PLA, No. 100, Xi Si Huan Zhong Lu, 100039, Beijing, China aut NATIONALLICENCE 700 1- Zhao Yuanyuan Department of Ultrasound, Qi Lu Hospital (Qing dao), Shandong University, 266000, Qingdao, China aut NATIONALLICENCE 700 1- Wang Ruifang Department of Ultrasound, The 302 Hospital of PLA, No. 100, Xi Si Huan Zhong Lu, 100039, Beijing, China aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 723-729 0942-8925 40:4<723 2015 40 261