caa a22 4500 605494347 CHVBK 20210128100525.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00261-014-0256-0 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0256-0 Prediction of microvascular invasion of hepatocellular carcinoma using gadoxetic acid-enhanced MR and 18F-FDG PET/CT [Elektronische Daten] [Su Ahn, Jeong Lee, Ijin Joo, Eun Lee, Soo Lee, Gi Cheon, Joon Han, Byung Choi] Purpose: To identify the gadoxetic acid-enhanced MR and the 18F-fludeoxyglucose (FDG) PET/CT findings associated with microvascular invasion (MVI) of hepatocellular carcinoma (HCC) in patients who are undergoing liver transplantation (LT). Methods: Fifty-one patients with 78 HCCs underwent LT. Preoperative MRI and 18F-FDG PET/CT findings were retrospectively analyzed and the association of the imaging findings with MVI was assessed. Results: Univariate analysis revealed that hypointensity seen on T1WI (OR=4.329, p=0.011), peritumoral enhancement (OR=7.000, p=0.008), inhomogeneity on arterial phase (OR=4.321, p=0.011), delayed phase (OR=4.519, p=0.009) or hepatobiliary phase (OR=3.564, p=0.032), and the large tumor size (>5cm) (OR=12.091, p=0.001) showed statistically significant associations with MVI. The ratio of tumor maximum standardized uptake value (SUV) to normal liver mean SUV (TSUVmax/LSUVmean) (2.05±1.43 vs. 1.08±0.37) revealed significantly higher value in the MVI-positive group. Multivariate analysis revealed that peritumoral enhancement and a TSUVmax/LSUVmean of 1.2 or greater had a statistically significant association with MVI, with odds ratios of 10.648 (p=0.016) and 14.218 (p=0.001), respectively. Conclusions: Preoperative imaging findings such as peritumoral enhancement seen on gadoxetic acid-enhanced MR and a TSUVmax/LSUVmean of 1.2 or more on 18F-FDG PET/CT, may suggest the presence of MVI in HCC patients. Springer Science+Business Media New York, 2014 Hepatocellular carcinoma nationallicence Microvascular invasion nationallicence Liver transplantation nationallicence MRI nationallicence PET/CT nationallicence Ahn Su Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut Lee Jeong Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut Joo Ijin Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut Lee Eun Department of Radiology, National Cancer Center, Goyang, Korea aut Lee Soo Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea aut Cheon Gi Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea aut Han Joon Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut Choi Byung Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 843-851 0942-8925 40:4<843 2015 40 261 https://doi.org/10.1007/s00261-014-0256-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0256-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ahn Su Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Jeong Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Joo Ijin Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Eun Department of Radiology, National Cancer Center, Goyang, Korea aut NATIONALLICENCE 700 1- Lee Soo Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Cheon Gi Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Han Joon Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Choi Byung Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 843-851 0942-8925 40:4<843 2015 40 261