Magnetic Resonance Elastography of Liver: Influence of Intravenous Gadolinium Administration on Measured Liver Stiffness
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| 024 | 7 | 0 | |a 10.1007/s00261-014-0275-x |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-014-0275-x | ||
| 245 | 0 | 0 | |a Magnetic Resonance Elastography of Liver: Influence of Intravenous Gadolinium Administration on Measured Liver Stiffness |h [Elektronische Daten] |c [James Hallinan, Hind Alsaif, Aileen Wee, Sudhakar Venkatesh] |
| 520 | 3 | |a Purpose: To evaluate the effect of intravenous gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) on estimation of liver stiffness using magnetic resonance elastography (MRE) for detection of liver fibrosis. Materials and methods: Liver MRI with MRE was performed in 210 subjects on a single 1.5 Tesla clinical MRI scanner. Liver MRE was performed before intravenous Gd-DTPA injection (NC-MRE) and 5 minutes post injection (PC-MRE) using a modified phase-contrast gradient-echo sequence (TR/TE=100/27ms, FOV=30-46cm, 4x10mm slices, gap 5mm) which automatically generated stiffness maps. Two readers' blinded to clinical details independently performed liver stiffness measurements (LSM) by drawing 2 or more regions of interest (ROI) on the stiffness maps on each of the four slices of NC-MRE and PC-MRE obtained for each patient. The mean LSM in kilopascals (kPa) for NC-MRE and PC-MRE was calculated. The correlation between NC-MRE and PC-MRE LSM was evaluated with a paired t test and Pearson's correlation analysis, and the inter-observer correlation was evaluated using intra class coefficient (ICC) analysis. A receiver operating curve analysis (ROC) was performed to compare accuracies for detection and staging of liver fibrosis in a subgroup of 72 subjects with histological confirmation of liver fibrosis. Results: There was an excellent correlation between NC-MRE and PC-MRE LSM (R2=0.98, p<0.001) with no significant differences. The interobserver agreement was also excellent (ICC, 0.94-0.99). There were no significant differences in the cut-off LSM value/accuracy/sensitivity/specificity for detection of significant liver fibrosis with NC-MRE and PC-MRE (2.98kPa/98.5%/100%/88%, p<0.001 and 3.1kPa/98.2%/98%/88%, p<0.001 respectively). Conclusion: Intravenous Gd-DTPA had no significant influence on LSM with MRE and does not significantly affect the diagnostic performance of MRE for fibrosis detection. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a Magnetic resonance elastography |2 nationallicence | |
| 690 | 7 | |a Liver fibrosis |2 nationallicence | |
| 690 | 7 | |a Intravenous Gd-DTPA |2 nationallicence | |
| 690 | 7 | |a Liver stiffness |2 nationallicence | |
| 700 | 1 | |a Hallinan |D James |u Diagnostic Imaging, National University Health System, Singapore, Singapore |4 aut | |
| 700 | 1 | |a Alsaif |D Hind |u Diagnostic Imaging, National University Health System, Singapore, Singapore |4 aut | |
| 700 | 1 | |a Wee |D Aileen |u Department of Pathology, National University Health System, Singapore, Singapore |4 aut | |
| 700 | 1 | |a Venkatesh |D Sudhakar |u Department of Radiology, Mayo Clinic, Rochester, 200, First Street SW, 55905, Rochester, MN, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/4(2015-04-01), 783-788 |x 0942-8925 |q 40:4<783 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-014-0275-x |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-014-0275-x |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hallinan |D James |u Diagnostic Imaging, National University Health System, Singapore, Singapore |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Alsaif |D Hind |u Diagnostic Imaging, National University Health System, Singapore, Singapore |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wee |D Aileen |u Department of Pathology, National University Health System, Singapore, Singapore |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Venkatesh |D Sudhakar |u Department of Radiology, Mayo Clinic, Rochester, 200, First Street SW, 55905, Rochester, MN, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/4(2015-04-01), 783-788 |x 0942-8925 |q 40:4<783 |1 2015 |2 40 |o 261 | ||