caa a22 4500 605494363 CHVBK 20210128100525.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00261-014-0275-x doi (NATIONALLICENCE)springer-10.1007/s00261-014-0275-x Magnetic Resonance Elastography of Liver: Influence of Intravenous Gadolinium Administration on Measured Liver Stiffness [Elektronische Daten] [James Hallinan, Hind Alsaif, Aileen Wee, Sudhakar Venkatesh] Purpose: To evaluate the effect of intravenous gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) on estimation of liver stiffness using magnetic resonance elastography (MRE) for detection of liver fibrosis. Materials and methods: Liver MRI with MRE was performed in 210 subjects on a single 1.5 Tesla clinical MRI scanner. Liver MRE was performed before intravenous Gd-DTPA injection (NC-MRE) and 5 minutes post injection (PC-MRE) using a modified phase-contrast gradient-echo sequence (TR/TE=100/27ms, FOV=30-46cm, 4x10mm slices, gap 5mm) which automatically generated stiffness maps. Two readers' blinded to clinical details independently performed liver stiffness measurements (LSM) by drawing 2 or more regions of interest (ROI) on the stiffness maps on each of the four slices of NC-MRE and PC-MRE obtained for each patient. The mean LSM in kilopascals (kPa) for NC-MRE and PC-MRE was calculated. The correlation between NC-MRE and PC-MRE LSM was evaluated with a paired t test and Pearson's correlation analysis, and the inter-observer correlation was evaluated using intra class coefficient (ICC) analysis. A receiver operating curve analysis (ROC) was performed to compare accuracies for detection and staging of liver fibrosis in a subgroup of 72 subjects with histological confirmation of liver fibrosis. Results: There was an excellent correlation between NC-MRE and PC-MRE LSM (R2=0.98, p<0.001) with no significant differences. The interobserver agreement was also excellent (ICC, 0.94-0.99). There were no significant differences in the cut-off LSM value/accuracy/sensitivity/specificity for detection of significant liver fibrosis with NC-MRE and PC-MRE (2.98kPa/98.5%/100%/88%, p<0.001 and 3.1kPa/98.2%/98%/88%, p<0.001 respectively). Conclusion: Intravenous Gd-DTPA had no significant influence on LSM with MRE and does not significantly affect the diagnostic performance of MRE for fibrosis detection. Springer Science+Business Media New York, 2014 Magnetic resonance elastography nationallicence Liver fibrosis nationallicence Intravenous Gd-DTPA nationallicence Liver stiffness nationallicence Hallinan James Diagnostic Imaging, National University Health System, Singapore, Singapore aut Alsaif Hind Diagnostic Imaging, National University Health System, Singapore, Singapore aut Wee Aileen Department of Pathology, National University Health System, Singapore, Singapore aut Venkatesh Sudhakar Department of Radiology, Mayo Clinic, Rochester, 200, First Street SW, 55905, Rochester, MN, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 783-788 0942-8925 40:4<783 2015 40 261 https://doi.org/10.1007/s00261-014-0275-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0275-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hallinan James Diagnostic Imaging, National University Health System, Singapore, Singapore aut NATIONALLICENCE 700 1- Alsaif Hind Diagnostic Imaging, National University Health System, Singapore, Singapore aut NATIONALLICENCE 700 1- Wee Aileen Department of Pathology, National University Health System, Singapore, Singapore aut NATIONALLICENCE 700 1- Venkatesh Sudhakar Department of Radiology, Mayo Clinic, Rochester, 200, First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 783-788 0942-8925 40:4<783 2015 40 261