caa a22 4500 605494371 CHVBK 20210128100525.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00261-014-0137-6 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0137-6 Magnetic resonance elastography and acoustic radiation force impulse for staging hepatic fibrosis: a meta-analysis [Elektronische Daten] [Yang Guo, Sudharshan Parthasarathy, Preeya Goyal, Robert McCarthy, Andrew Larson, Frank Miller] Purpose: Elastography is a non-invasive method to quantify fibrosis based on tissue mechanical properties. We performed a meta-analysis to assess the diagnostic accuracy of two such techniques: Acoustic Radiation Force Impulse Imaging (ARFI) or Magnetic Resonance Elastography (MRE) for staging hepatic fibrosis. Materials and Methods: Literature databases were searched until June 2013. Inclusion criteria were evaluation of MRE or ARFI, liver biopsy, and reported sensitivity and specificity. A random effects model was used to combine sensitivity and specificity, from which positive (LR+) and negative (LR−) likelihood ratios, diagnostic odds ratios, and area under receiver operating characteristics curve (AUROC) were derived. Differences between MRE and ARFI were compared with t tests (P<0.05 considered significant). Results: Eleven MRE studies including 982 patients and fifteen ARFI studies including 2,128 patients were selected. AUROC for MRE staging fibrosis were 0.94, 0.97, 0.96, and 0.97 for F1-F4, respectively, whereas AUROC for ARFI staging were 0.82, 0.85, 0.94, and 0.94 for F1-F4, respectively. Significance was found in AUROC between MRE and ARFI for the diagnosis of stage 1 and 2 fibrosis. Conclusion: MRE is more accurate than ARFI with a higher combination of sensitivity, specificity, LR, and AUROC particularly in diagnosing early stages of hepatic fibrosis. Springer Science+Business Media New York, 2014 Hepatic fibrosis nationallicence Magnetic resonance imaging nationallicence MR elastography nationallicence Acoustic radiation force impulse nationallicence Meta-analysis nationallicence APRI : Aspartate aminotransferase-to-platelet ratio index nationallicence ARFI : Acoustic radiation force impulse nationallicence AUROC : Area under the receiver operating characteristic curve nationallicence ALD : Alcoholic liver disease nationallicence AIH : Autoimmune hepatitis nationallicence BMI : Body mass index nationallicence CLD : Chronic liver disease nationallicence CHC : Chronic hepatitis C nationallicence CHB : Chronic hepatitis B nationallicence CI : Confidence interval nationallicence CT : Computed tomography nationallicence DOR : Diagnostic odds ratio nationallicence ECM : Extracellular matrix nationallicence FP : False positive nationallicence FN : False negative nationallicence HIV : Human immunodeficiency virus nationallicence HCV : Hepatitis C virus nationallicence kPa : kilopascal nationallicence LR+ : Positive likelihood ratio nationallicence LR− : Negative likelihood ratio nationallicence MRE : Magnetic resonance elastography nationallicence NPV : Negative predictive value nationallicence NAFLD : Non-alcoholic fatty liver disease nationallicence NASH : Non-alcoholic steatohepatitis nationallicence PPV : Positive predictive value nationallicence PBC : Primary biliary cirrhosis nationallicence PSC : Primary sclerosing cholangitis nationallicence ROC : Receiver operating characteristics nationallicence Se : Sensitivity nationallicence Sp : Specificity nationallicence TE : Transient elastography nationallicence TP : True positive nationallicence TN : True negative nationallicence US : Ultrasound nationallicence Guo Yang Department of Radiology, Northwestern University Feinberg School of Medicine, NMH/Arkes Family Pavilion Suite 800, 676N Saint Clair, 60611, Chicago, IL, USA aut Parthasarathy Sudharshan Chicago Medical School, Rosalind Franklin University of Medicine, Chicago, IL, USA aut Goyal Preeya Department of Radiology, Northwestern University Feinberg School of Medicine, NMH/Arkes Family Pavilion Suite 800, 676N Saint Clair, 60611, Chicago, IL, USA aut McCarthy Robert Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA aut Larson Andrew Department of Radiology, Northwestern University Feinberg School of Medicine, NMH/Arkes Family Pavilion Suite 800, 676N Saint Clair, 60611, Chicago, IL, USA aut Miller Frank Department of Radiology, Northwestern University Feinberg School of Medicine, NMH/Arkes Family Pavilion Suite 800, 676N Saint Clair, 60611, Chicago, IL, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 818-834 0942-8925 40:4<818 2015 40 261 https://doi.org/10.1007/s00261-014-0137-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0137-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Guo Yang Department of Radiology, Northwestern University Feinberg School of Medicine, NMH/Arkes Family Pavilion Suite 800, 676N Saint Clair, 60611, Chicago, IL, USA aut NATIONALLICENCE 700 1- Parthasarathy Sudharshan Chicago Medical School, Rosalind Franklin University of Medicine, Chicago, IL, USA aut NATIONALLICENCE 700 1- Goyal Preeya Department of Radiology, Northwestern University Feinberg School of Medicine, NMH/Arkes Family Pavilion Suite 800, 676N Saint Clair, 60611, Chicago, IL, USA aut NATIONALLICENCE 700 1- McCarthy Robert Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA aut NATIONALLICENCE 700 1- Larson Andrew Department of Radiology, Northwestern University Feinberg School of Medicine, NMH/Arkes Family Pavilion Suite 800, 676N Saint Clair, 60611, Chicago, IL, USA aut NATIONALLICENCE 700 1- Miller Frank Department of Radiology, Northwestern University Feinberg School of Medicine, NMH/Arkes Family Pavilion Suite 800, 676N Saint Clair, 60611, Chicago, IL, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/4(2015-04-01), 818-834 0942-8925 40:4<818 2015 40 261