caa a22 4500 605494401 CHVBK 20210128100525.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0539-0 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0539-0 T1-hyperintense renal lesions: can high signal predict lack of enhancement? [Elektronische Daten] [Jenna Le, Milana Flusberg, Alla Rozenblit, Victoria Chernyak] Objective: To establish highly specific criteria for predicting non-enhancement in T1-hyperintense non-fat-containing (T1-high) renal lesions using unenhanced fat-suppressed T1-weighted (T1-FS) images. Materials and methods: This IRB-approved, HIPAA-compliant, retrospective study included T1-high renal lesions found between 7/1/2012 and 7/1/2014. The largest lesion diameter and heterogeneity, mean signal intensity of lesion, and adjacent renal cortex were recorded from T1-FS images. The presence/absence of lesion enhancement was determined from subtraction images. T1 signal ratio (T1-SR) was calculated as (mean SI of lesion)/(mean SI of cortex). Logistic regression with binary outcome of the presence or absence of lesion enhancement was performed. Cut-off T1-SR to maximize specificity was established from receiver operator curve analysis. Results: There were 101 patients (58 [57.4%] male) with non-enhancing lesions and 80 patients (51 [63.8%] male) with enhancing lesions, mean ages 64.0±13.3 and 62.1±13.8years, respectively. Median sizes were 11mm (IQR 8-16) and 20.5mm (IQR 15-29) for non-enhancing and enhancing lesions, respectively (p<0.0001). 19/101 (18.8%) of non-enhancing and 56/80 (70.0%) of enhancing lesions were heterogeneous (p<0.0001). T1-SR was 1.77±0.6 and 1.25±0.42 for non-enhancing and enhancing lesions, respectively (p<0.0001). For each increase of 0.5 in T1-SR, odds ratio for non-enhancement was 3.3 (95% CI 1.85-5.79), adjusted for lesion size and heterogeneity. T1-SR alone had area under the curve of 0.88 (95% CI 0.78-10.89) for non-enhancement. T1-SR ≥2.15 had positive likelihood ratio of 9.5 for non-enhancement. Conclusion: Signal ratio of lesion to cortex ≥2.15 on unenhanced T1-weighted images is a highly specific predictor for non-enhancement. Springer Science+Business Media New York, 2015 Renal masses nationallicence Renal cell carcinoma nationallicence Renal cysts nationallicence Incidentalomas nationallicence Le Jenna Department of Radiology, Montefiore Medical Center, 111 E. 210th St., 10467, Bronx, NY, USA aut Flusberg Milana Department of Radiology, Montefiore Medical Center, 111 E. 210th St., 10467, Bronx, NY, USA aut Rozenblit Alla Department of Radiology, Montefiore Medical Center, 111 E. 210th St., 10467, Bronx, NY, USA aut Chernyak Victoria Department of Radiology, Montefiore Medical Center, 111 E. 210th St., 10467, Bronx, NY, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3175-3181 0942-8925 40:8<3175 2015 40 261 https://doi.org/10.1007/s00261-015-0539-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0539-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Le Jenna Department of Radiology, Montefiore Medical Center, 111 E. 210th St., 10467, Bronx, NY, USA aut NATIONALLICENCE 700 1- Flusberg Milana Department of Radiology, Montefiore Medical Center, 111 E. 210th St., 10467, Bronx, NY, USA aut NATIONALLICENCE 700 1- Rozenblit Alla Department of Radiology, Montefiore Medical Center, 111 E. 210th St., 10467, Bronx, NY, USA aut NATIONALLICENCE 700 1- Chernyak Victoria Department of Radiology, Montefiore Medical Center, 111 E. 210th St., 10467, Bronx, NY, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3175-3181 0942-8925 40:8<3175 2015 40 261