caa a22 4500 605494436 CHVBK 20210128100526.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0544-3 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0544-3 Standardized uptake value on positron emission tomography/computed tomography predicts prognosis in patients with locally advanced pancreatic cancer [Elektronische Daten] [Si-Liang Wang, Shuo Cao, Yu-Nan Sun, Rong Wu, Feng Chi, Mei-Yue Tang, Xue-Ying Jin, Xiao-Dong Chen] Background: The aim of the present study was to investigate the use and value of maximum standardized uptake value (SUVmax) on positron emission tomography/computed tomography (PET/CT) images as a prognostic marker for patients with locally advanced pancreatic cancer (LAPC). Materials and methods: The medical records of all consecutive patients who underwent PET/CT examination in our institution were retrospectively reviewed. Inclusion criteria were histologically or cytologically proven LAPC. Patients with distant metastasis were excluded. For statistical analysis, the SUVmax of primary pancreatic cancer was measured. Survival rates were calculated using the Kaplan-Meier method, and multivariable analysis was performed to determine the association of SUVmax with overall survival (OS) and progression-free survival (PFS) using a Cox proportional hazards model. Results: Between July 2006 and June 2013, 69 patients were enrolled in the present study. OS and PFS were 14.9months [95% confidence interval (CI) 13.1-16.7] and 8.3months (95% CI 7.1-9.5), respectively. A high SUVmax (>5.5) was observed in 35 patients, who had significantly worse OS and PFS than the remaining patients with a low SUVmax (P=0.025 and P=0.003). Univariate analysis showed that SUVmax and tumor size were prognostic factors for OS, with a hazard ratio of 1.90 and 1.81, respectively. A high SUVmax was an independent prognostic factor, with a hazard ratio of 1.89 (95% CI 1.015-3.519, P=0.045). Conclusion: The present study suggests that increased SUVmax is a predictor of poor prognosis in patients with LAPC. Springer Science+Business Media New York, 2015 Locally advanced pancreatic carcinoma nationallicence Standardized uptake value nationallicence Positron emission tomography/computed tomography nationallicence Chemoradiotherapy nationallicence Prognosis nationallicence Wang Si-Liang Department of Medical Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut Cao Shuo Department of Medical Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut Sun Yu-Nan Department of Medical Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut Wu Rong Department of Medical Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut Chi Feng Department of Medical Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut Tang Mei-Yue Department of Medical Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut Jin Xue-Ying Department of Medical Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut Chen Xiao-Dong Department of Medical Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3117-3121 0942-8925 40:8<3117 2015 40 261 https://doi.org/10.1007/s00261-015-0544-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0544-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Si-Liang Department of Medical Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut NATIONALLICENCE 700 1- Cao Shuo Department of Medical Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut NATIONALLICENCE 700 1- Sun Yu-Nan Department of Medical Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut NATIONALLICENCE 700 1- Wu Rong Department of Medical Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut NATIONALLICENCE 700 1- Chi Feng Department of Medical Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut NATIONALLICENCE 700 1- Tang Mei-Yue Department of Medical Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut NATIONALLICENCE 700 1- Jin Xue-Ying Department of Medical Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut NATIONALLICENCE 700 1- Chen Xiao-Dong Department of Medical Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, 110004, Shenyang, China aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3117-3121 0942-8925 40:8<3117 2015 40 261