DWI-associated entire-tumor histogram analysis for the differentiation of low-grade prostate cancer from intermediate-high-grade prostate cancer
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| 024 | 7 | 0 | |a 10.1007/s00261-015-0499-4 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-015-0499-4 | ||
| 245 | 0 | 0 | |a DWI-associated entire-tumor histogram analysis for the differentiation of low-grade prostate cancer from intermediate-high-grade prostate cancer |h [Elektronische Daten] |c [Chen-Jiang Wu, Qing Wang, Hai Li, Xiao-Ning Wang, Xi-Sheng Liu, Hai-Bin Shi, Yu-Dong Zhang] |
| 520 | 3 | |a Purpose: To investigate diagnostic efficiency of DWI using entire-tumor histogram analysis in differentiating the low-grade (LG) prostate cancer (PCa) from intermediate-high-grade (HG) PCa in comparison with conventional ROI-based measurement. Methods: DW images (b of 0-1400s/mm2) from 126 pathology-confirmed PCa (diameter >0.5cm) in 110 patients were retrospectively collected and processed by mono-exponential model. The measurement of tumor apparent diffusion coefficients (ADCs) was performed with using histogram-based and ROI-based approach, respectively. The diagnostic ability of ADCs from two methods for differentiating LG-PCa (Gleason score, GS ≤6) from HG-PCa (GS>6) was determined by ROC regression, and compared by McNemar's test. Results: There were 49 LG-tumor and 77 HG-tumor at pathologic findings. Histogram-based ADCs (mean, median, 10th and 90th) and ROI-based ADCs (mean) showed dominant relationships with ordinal GS of Pca (ρ=−0.225 to −0.406, p<0.05). All above imaging indices reflected significant difference between LG-PCa and HG-PCa (all p values <0.01). Histogram 10th ADCs had dominantly high Az (0.738), Youden index (0.415), and positive likelihood ratio (LR+, 2.45) in stratifying tumor GS against mean, median and 90th ADCs, and ROI-based ADCs. Histogram mean, median, and 10th ADCs showed higher specificity (65.3%-74.1% vs. 44.9%, p<0.01), but lower sensitivity (57.1%-71.3% vs. 84.4%, p<0.05) than ROI-based ADCs in differentiating LG-PCa from HG-PCa. Conclusions: DWI-associated histogram analysis had higher specificity, Az, Youden index, and LR+ for differentiation of PCa Gleason grade than ROI-based approach. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a DWI |2 nationallicence | |
| 690 | 7 | |a ADC |2 nationallicence | |
| 690 | 7 | |a ROI |2 nationallicence | |
| 690 | 7 | |a Histogram analysis |2 nationallicence | |
| 700 | 1 | |a Wu |D Chen-Jiang |u Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China |4 aut | |
| 700 | 1 | |a Wang |D Qing |u Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China |4 aut | |
| 700 | 1 | |a Li |D Hai |u Department of Pathology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China |4 aut | |
| 700 | 1 | |a Wang |D Xiao-Ning |u Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China |4 aut | |
| 700 | 1 | |a Liu |D Xi-Sheng |u Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China |4 aut | |
| 700 | 1 | |a Shi |D Hai-Bin |u Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China |4 aut | |
| 700 | 1 | |a Zhang |D Yu-Dong |u Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/8(2015-10-01), 3214-3221 |x 0942-8925 |q 40:8<3214 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-015-0499-4 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-015-0499-4 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wu |D Chen-Jiang |u Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wang |D Qing |u Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Li |D Hai |u Department of Pathology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wang |D Xiao-Ning |u Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Liu |D Xi-Sheng |u Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shi |D Hai-Bin |u Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhang |D Yu-Dong |u Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/8(2015-10-01), 3214-3221 |x 0942-8925 |q 40:8<3214 |1 2015 |2 40 |o 261 | ||