caa a22 4500 605494487 CHVBK 20210128100526.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0499-4 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0499-4 DWI-associated entire-tumor histogram analysis for the differentiation of low-grade prostate cancer from intermediate-high-grade prostate cancer [Elektronische Daten] [Chen-Jiang Wu, Qing Wang, Hai Li, Xiao-Ning Wang, Xi-Sheng Liu, Hai-Bin Shi, Yu-Dong Zhang] Purpose: To investigate diagnostic efficiency of DWI using entire-tumor histogram analysis in differentiating the low-grade (LG) prostate cancer (PCa) from intermediate-high-grade (HG) PCa in comparison with conventional ROI-based measurement. Methods: DW images (b of 0-1400s/mm2) from 126 pathology-confirmed PCa (diameter >0.5cm) in 110 patients were retrospectively collected and processed by mono-exponential model. The measurement of tumor apparent diffusion coefficients (ADCs) was performed with using histogram-based and ROI-based approach, respectively. The diagnostic ability of ADCs from two methods for differentiating LG-PCa (Gleason score, GS ≤6) from HG-PCa (GS>6) was determined by ROC regression, and compared by McNemar's test. Results: There were 49 LG-tumor and 77 HG-tumor at pathologic findings. Histogram-based ADCs (mean, median, 10th and 90th) and ROI-based ADCs (mean) showed dominant relationships with ordinal GS of Pca (ρ=−0.225 to −0.406, p<0.05). All above imaging indices reflected significant difference between LG-PCa and HG-PCa (all p values <0.01). Histogram 10th ADCs had dominantly high Az (0.738), Youden index (0.415), and positive likelihood ratio (LR+, 2.45) in stratifying tumor GS against mean, median and 90th ADCs, and ROI-based ADCs. Histogram mean, median, and 10th ADCs showed higher specificity (65.3%-74.1% vs. 44.9%, p<0.01), but lower sensitivity (57.1%-71.3% vs. 84.4%, p<0.05) than ROI-based ADCs in differentiating LG-PCa from HG-PCa. Conclusions: DWI-associated histogram analysis had higher specificity, Az, Youden index, and LR+ for differentiation of PCa Gleason grade than ROI-based approach. Springer Science+Business Media New York, 2015 DWI nationallicence ADC nationallicence ROI nationallicence Histogram analysis nationallicence Wu Chen-Jiang Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China aut Wang Qing Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China aut Li Hai Department of Pathology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China aut Wang Xiao-Ning Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China aut Liu Xi-Sheng Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China aut Shi Hai-Bin Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China aut Zhang Yu-Dong Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3214-3221 0942-8925 40:8<3214 2015 40 261 https://doi.org/10.1007/s00261-015-0499-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0499-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wu Chen-Jiang Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China aut NATIONALLICENCE 700 1- Wang Qing Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China aut NATIONALLICENCE 700 1- Li Hai Department of Pathology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China aut NATIONALLICENCE 700 1- Wang Xiao-Ning Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China aut NATIONALLICENCE 700 1- Liu Xi-Sheng Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China aut NATIONALLICENCE 700 1- Shi Hai-Bin Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China aut NATIONALLICENCE 700 1- Zhang Yu-Dong Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, 210000, Nanjing, China aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3214-3221 0942-8925 40:8<3214 2015 40 261