caa a22 4500 605494517 CHVBK 20210128100526.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0506-9 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0506-9 Feasibility of and agreement between MR imaging and spectroscopic estimation of hepatic proton density fat fraction in children with known or suspected nonalcoholic fatty liver disease [Elektronische Daten] [Emil Achmad, Takeshi Yokoo, Gavin Hamilton, Elhamy Heba, Jonathan Hooker, Christopher Changchien, Michael Schroeder, Tanya Wolfson, Anthony Gamst, Jeffrey Schwimmer, Joel Lavine, Claude Sirlin, Michael Middleton] Purpose: To assess feasibility of and agreement between magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) for estimating hepatic proton density fat fraction (PDFF) in children with known or suspected nonalcoholic fatty liver disease (NAFLD). Materials and methods: Children were included in this study from two previous research studies in each of which three MRI and three MRS acquisitions were obtained. Sequence acceptability, and MRI- and MRS-estimated PDFF were evaluated. Agreement of MRI- with MRS-estimated hepatic PDFF was assessed by linear regression and Bland-Altman analysis. Age, sex, BMI-Z score, acquisition time, and artifact score effects on MRI- and MRS-estimated PDFF agreement were assessed by multiple linear regression. Results: Eighty-six children (61 boys and 25 girls) were included in this study. Slope and intercept from regressing MRS-PDFF on MRI-PDFF were 0.969 and 1.591%, respectively, and the Bland-Altman bias and 95% limits of agreement were 1.17%±2.61%. MRI motion artifact score was higher in boys than girls (by 0.21, p=0.021). Higher BMI-Z score was associated with lower agreement between MRS and MRI (p=0.045). Conclusion: Hepatic PDFF estimation by both MRI and MRS is feasible, and MRI- and MRS-estimated PDFF agree closely in children with known or suspected NAFLD. Springer Science+Business Media New York, 2015 MRI nationallicence MRS nationallicence NAFLD nationallicence Proton density fat fraction nationallicence PDFF nationallicence Steatosis nationallicence Achmad Emil Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut Yokoo Takeshi Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut Hamilton Gavin Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut Heba Elhamy Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut Hooker Jonathan Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut Changchien Christopher Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut Schroeder Michael Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut Wolfson Tanya Computational and Applied Statistics Laboratory (CASL), San Diego Supercomputing Center (SDSC), University of California, San Diego, San Diego, CA, USA aut Gamst Anthony Computational and Applied Statistics Laboratory (CASL), San Diego Supercomputing Center (SDSC), University of California, San Diego, San Diego, CA, USA aut Schwimmer Jeffrey Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut Lavine Joel Department of Pediatrics, Columbia University, New York, NY, USA aut Sirlin Claude Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut Middleton Michael Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3084-3090 0942-8925 40:8<3084 2015 40 261 https://doi.org/10.1007/s00261-015-0506-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0506-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Achmad Emil Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut NATIONALLICENCE 700 1- Yokoo Takeshi Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut NATIONALLICENCE 700 1- Hamilton Gavin Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut NATIONALLICENCE 700 1- Heba Elhamy Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut NATIONALLICENCE 700 1- Hooker Jonathan Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut NATIONALLICENCE 700 1- Changchien Christopher Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut NATIONALLICENCE 700 1- Schroeder Michael Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut NATIONALLICENCE 700 1- Wolfson Tanya Computational and Applied Statistics Laboratory (CASL), San Diego Supercomputing Center (SDSC), University of California, San Diego, San Diego, CA, USA aut NATIONALLICENCE 700 1- Gamst Anthony Computational and Applied Statistics Laboratory (CASL), San Diego Supercomputing Center (SDSC), University of California, San Diego, San Diego, CA, USA aut NATIONALLICENCE 700 1- Schwimmer Jeffrey Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut NATIONALLICENCE 700 1- Lavine Joel Department of Pediatrics, Columbia University, New York, NY, USA aut NATIONALLICENCE 700 1- Sirlin Claude Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut NATIONALLICENCE 700 1- Middleton Michael Liver Imaging Group, Department of Radiology, School of Medicine, University of California, San Diego, San Diego, CA, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3084-3090 0942-8925 40:8<3084 2015 40 261