caa a22 4500 605494541 CHVBK 20210128100526.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0522-9 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0522-9 Accurate estimate of pancreatic T2* values: how to deal with fat infiltration [Elektronische Daten] [Antonella Meloni, Daniele De Marchi, Vincenzo Positano, Maria Neri, Maurizio Mangione, Petra Keilberg, Maddalena Lendini, Carla Cirotto, Alessia Pepe] Purpose: We examined different approaches aimed to deal with the signal fluctuation of pancreatic T2* values due to fat infiltration in order to obtain accurate estimates of iron overload. Methods: Pancreatic T2* values were assessed in 20 patients (13 females, 37.24±9.12years) enrolled in the Myocardial Iron Overload in Thalassemia network without and with the application of fat suppression-FS (T2*-NoFS and T2*-FS). T2* values were assessed in three different ways: (1) from the immediate fit (original T2*); (2) discarding the echoes until the achievement of a good visual concordance between the signal and the model (final_vis T2*); (3) eliminating the echoes until the achievement of a fitting error (known)<5% (final_thres T2*). Results: For the T2*-NoFS sequence the original T2* values were significantly higher than the final_vis T2* values (difference:4.8±6.1ms; P<0.0001) and the final_thres T2* values (difference:4.3±6.1ms; P=0.006). For the T2*-FS sequence the original T2* values were comparable to final_vis and final_thres T2* values. The original T2*-FS values were significantly different from the original T2*-NoFS values. The final_vis T2*-FS values were comparable to the final_vis T2*-NoFS values and the final_thresh T2*-FS values were comparable to the final_thresh T2*-NoFS values. For both T2*-FS and T2*-NoFS sequences, the final_thres T2* values were not significantly different from the final_vis T2* values and no bias was present. Conclusions: In the clinical practice, an accurate pancreatic iron overload assessment should be done by applying FS and, when needed, by discarding the TEs until the fitting error goes below 5%. Springer Science+Business Media New York, 2015 Magnetic resonance imaging nationallicence Pancreas T2* nationallicence Iron overload nationallicence Fat suppression nationallicence Meloni Antonella CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut De Marchi Daniele CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut Positano Vincenzo CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut Neri Maria CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut Mangione Maurizio U.O.S. Sistemi Informatici, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy aut Keilberg Petra CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut Lendini Maddalena Centro Trasfusionale, Osp. Giovanni Paolo II, Olbia, Italy aut Cirotto Carla Servizio Trasfusionale, Azienda USL n° 1, Sassari, Italy aut Pepe Alessia CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3129-3136 0942-8925 40:8<3129 2015 40 261 https://doi.org/10.1007/s00261-015-0522-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0522-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Meloni Antonella CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut NATIONALLICENCE 700 1- De Marchi Daniele CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut NATIONALLICENCE 700 1- Positano Vincenzo CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut NATIONALLICENCE 700 1- Neri Maria CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut NATIONALLICENCE 700 1- Mangione Maurizio U.O.S. Sistemi Informatici, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy aut NATIONALLICENCE 700 1- Keilberg Petra CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut NATIONALLICENCE 700 1- Lendini Maddalena Centro Trasfusionale, Osp. Giovanni Paolo II, Olbia, Italy aut NATIONALLICENCE 700 1- Cirotto Carla Servizio Trasfusionale, Azienda USL n° 1, Sassari, Italy aut NATIONALLICENCE 700 1- Pepe Alessia CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Area della Ricerca S. Cataldo, Via Moruzzi, 1, 56124, Pisa, Italy aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3129-3136 0942-8925 40:8<3129 2015 40 261