caa a22 4500 605494606 CHVBK 20210128100527.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0527-4 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0527-4 Spectrum of IgG4-related disease on multi-detector CT: a 5-year study of a single medical center data [Elektronische Daten] [Yonglan He, Xuechao Du, Ning Ding, Zhuo Li, Weixun Zhou, Bo Chen, Zhengyu Jin, Hao Sun, Liang Zhu, Huadan Xue] Purpose: To discuss the diverse imaging features of pancreatic and extra-pancreatic lesions of IgG4-related disease (IgG4-RD) on multi-detector CT (MDCT). Methods: This retrospective study was approved by our institutional research ethics board, and informed consent was waived. From 2008 to 2013, 159 patients including 120 men (mean age 57years; range 27-79years) and 39 women (mean age 51years; range 25-83years) who met the comprehensive diagnostic criteria for IgG4-RD (2011) were enrolled. MDCT images consisted of 153 abdominal images, 64 pelvic images, 64 thoracic images, and 8 neck images were retrospectively analyzed in consensus by two radiologists with expertise in the CT diagnosis of IgG4-RD. Results: Only 11 (11/153, 7.2%) IgG4-RD patients had been found with no pancreatic involvement. 145 (145/159, 91.2%) patients had various extra-pancreatic lesions, including involvement of biliary tree (93/153, 60.8%), peri-pancreatic vessels (66/153, 43.1%), IgG4-related lymphadenopathy, peri-abdominal aorta arteritis or retroperitoneal fibrosis, head and neck lesions, etc. Renal lesions were found in 26 (26/153, 17.0%) IgG4-RD patients with 4 types of renal parenchymal involvement. Lung lesions were found in 44 (44/64, 68.7%) IgG4-RD patients, which were classified into 7 types. Conclusions: Pancreatic and various extra-pancreatic lesions may be involved in IgG4-RD patients frequently with typical imaging findings. It is useful to recognize the atypical or uncommon imaging features to help the diagnosis of IgG4-RD together with other serologic or histopathologic findings. Springer Science+Business Media New York, 2015 IgG4-related disease nationallicence Multi-detector CT nationallicence Pancreatic lesions nationallicence Extra-pancreatic lesions nationallicence He Yonglan Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., 100730, Beijing, People's Republic of China aut Du Xuechao Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., 100730, Beijing, People's Republic of China aut Ding Ning Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., 100730, Beijing, People's Republic of China aut Li Zhuo Amcare Clinic, Beijing, People's Republic of China aut Zhou Weixun Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People's Republic of China aut Chen Bo Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People's Republic of China aut Jin Zhengyu Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., 100730, Beijing, People's Republic of China aut Sun Hao Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., 100730, Beijing, People's Republic of China aut Zhu Liang Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., 100730, Beijing, People's Republic of China aut Xue Huadan Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., 100730, Beijing, People's Republic of China aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3104-3116 0942-8925 40:8<3104 2015 40 261 https://doi.org/10.1007/s00261-015-0527-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0527-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- He Yonglan Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., 100730, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Du Xuechao Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., 100730, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Ding Ning Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., 100730, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Li Zhuo Amcare Clinic, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Zhou Weixun Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Chen Bo Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Jin Zhengyu Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., 100730, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Sun Hao Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., 100730, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Zhu Liang Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., 100730, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Xue Huadan Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan #1, Dongcheng Dist., 100730, Beijing, People's Republic of China aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3104-3116 0942-8925 40:8<3104 2015 40 261