caa a22 4500 605494649 CHVBK 20210128100527.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0519-4 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0519-4 Amyloidosis of the liver on shear wave elastography: case report and review of literature [Elektronische Daten] [Dmitry Trifanov, Manish Dhyani, Jacob Bledsoe, Joseph Misdraji, Atul Bhan, Raymond Chung, Anthony Samir] Amyloidosis is extremely rare, with an estimated 2225 new US cases reported annually. Signs and symptoms of the disease are subtle and imaging findings are not pathognomonic. Currently, diagnosis requires biopsy to demonstrate the deposition of amyloid. Elastography is a new imaging modality that evaluates tissue elasticity. It has shown to have efficacy in characterizing thyroid nodules, detecting prostate cancer, and staging liver fibrosis. We present a case of hepatic amyloidosis in a 51-year-old male that demonstrates significantly increased stiffness with a median value of 99.1kPa (range 25.7-188.9kPa) on shear-wave elastography (SWE) imaging, which is significantly higher than thecut-off range reported for cirrhosis on SWE (10.4-11.5kPa). This finding raises the possibility that elastographic imaging may be sensitive to tissue mechanical changes induced by amyloid deposition. Springer Science+Business Media New York, 2015 Amyloidosis nationallicence Elastography nationallicence Liver fibrosis nationallicence Liver biopsy nationallicence SWE nationallicence Ultrasound elastography nationallicence Trifanov Dmitry Department of Abdominal Imaging and Intervention, Massachusetts General Hospital [MGH], Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA aut Dhyani Manish Department of Abdominal Imaging and Intervention, Massachusetts General Hospital [MGH], Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA aut Bledsoe Jacob Department of Pathology, Massachusetts General Hospital [MGH], Harvard Medical School, 02114, Boston, MA, USA aut Misdraji Joseph Department of Pathology, Massachusetts General Hospital [MGH], Harvard Medical School, 02114, Boston, MA, USA aut Bhan Atul Department of Pathology, Massachusetts General Hospital [MGH], Harvard Medical School, 02114, Boston, MA, USA aut Chung Raymond Department of Hepatology, Medicine, Massachusetts General Hospital [MGH], Harvard Medical School, 02114, Boston, MA, USA aut Samir Anthony Department of Abdominal Imaging and Intervention, Massachusetts General Hospital [MGH], Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3078-3083 0942-8925 40:8<3078 2015 40 261 https://doi.org/10.1007/s00261-015-0519-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0519-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Trifanov Dmitry Department of Abdominal Imaging and Intervention, Massachusetts General Hospital [MGH], Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Dhyani Manish Department of Abdominal Imaging and Intervention, Massachusetts General Hospital [MGH], Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Bledsoe Jacob Department of Pathology, Massachusetts General Hospital [MGH], Harvard Medical School, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Misdraji Joseph Department of Pathology, Massachusetts General Hospital [MGH], Harvard Medical School, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Bhan Atul Department of Pathology, Massachusetts General Hospital [MGH], Harvard Medical School, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Chung Raymond Department of Hepatology, Medicine, Massachusetts General Hospital [MGH], Harvard Medical School, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Samir Anthony Department of Abdominal Imaging and Intervention, Massachusetts General Hospital [MGH], Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3078-3083 0942-8925 40:8<3078 2015 40 261