caa a22 4500 605494673 CHVBK 20210128100527.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0503-z doi (NATIONALLICENCE)springer-10.1007/s00261-015-0503-z Correlation between Gd-EOB-DTPA-enhanced MR imaging findings and OATP1B3 expression in chemotherapy-associated sinusoidal obstruction syndrome [Elektronische Daten] [Norihide Yoneda, Osamu Matsui, Hiroshi Ikeno, Dai Inoue, Kotaro Yoshida, Azusa Kitao, Kazuto Kozaka, Satoshi Kobayashi, Toshifumi Gabata, Hiroko Ikeda, Keishi Nakamura, Tetsuo Ohta] We report a female case of sinusoidal obstruction syndrome (SOS) diagnosed pathologically after chemotherapy (Pmab+m-FOLFOX6) for ascending colon cancer with multiple liver metastases, focusing on the findings of gadoxetic acid-enhanced MRI (EOB-MRI) and the organic anion transporting polypeptide 1B3 (OATP1B3) expression of in the liver. The patient was a 75-year-old female. She had received chemotherapy (Pmab+m-FOLFOX6) as six cycles for preoperative chemotherapy. After the preoperative chemotherapy, tumor sizes of hepatic metastases were reduced and hepatobiliary phase of EOB-MRI clearly depicted diffuse reticular hypointensity in the background liver. On the other hand, dynamic CT and/or other sequences of EOB-MRI did not show definite abnormality in the background liver. After the operation, this patient was pathologically confirmed as SOS demonstrating centrilobular congestion, sinusoidal dilatation, and perisinusoidal fibrosis. In normal liver parenchyma, OATP1B3 (uptake transporter of the EOB-MRI) expression is observed predominantly in centrilobular hepatocytes (zone 3). On the other hand, OATP1B3 expression was remarkably reduced because of the damages in the centrilobular (zone 3) hepatocytes in this SOS case. This indicated that EOB-MRI might be extremely sensitive in diagnosing SOS in its early stage. Springer Science+Business Media New York, 2015 Sinusoidal obstruction syndrome nationallicence Oxaliplatin nationallicence OATP1B3 nationallicence Gd-EOB-DTPA nationallicence Yoneda Norihide Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut Matsui Osamu Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut Ikeno Hiroshi Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut Inoue Dai Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut Yoshida Kotaro Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut Kitao Azusa Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut Kozaka Kazuto Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut Kobayashi Satoshi Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut Gabata Toshifumi Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut Ikeda Hiroko Division of Pathology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut Nakamura Keishi Department of Gastroenterologic Surgery, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut Ohta Tetsuo Department of Gastroenterologic Surgery, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3099-3103 0942-8925 40:8<3099 2015 40 261 https://doi.org/10.1007/s00261-015-0503-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0503-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoneda Norihide Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 700 1- Matsui Osamu Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 700 1- Ikeno Hiroshi Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 700 1- Inoue Dai Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 700 1- Yoshida Kotaro Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 700 1- Kitao Azusa Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 700 1- Kozaka Kazuto Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 700 1- Kobayashi Satoshi Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 700 1- Gabata Toshifumi Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 700 1- Ikeda Hiroko Division of Pathology, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 700 1- Nakamura Keishi Department of Gastroenterologic Surgery, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 700 1- Ohta Tetsuo Department of Gastroenterologic Surgery, Kanazawa University Hospital, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3099-3103 0942-8925 40:8<3099 2015 40 261