caa a22 4500 605494703 CHVBK 20210128100527.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0536-3 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0536-3 MR features of small hepatocellular carcinoma in normal, fibrotic, and cirrhotic livers: a comparative study [Elektronische Daten] [Ruo Sheng, Meng Zeng, Yuan Ji, Li Yang, Cai Chen, Sheng Rao] Purpose: The objective of this study is to compare MR imaging features of small hepatocellular carcinoma (HCC) (≤2cm) in normal, fibrotic, and cirrhotic liver. Methods: A total of 215 patients with 235 pathologically proven sHCC were retrospectively analyzed. Patients were classified into three groups according to the patients' liver condition: patients with normal liver (F0, group 1), fibrosis without cirrhosis (F1-3, group 2), and cirrhosis (F4, group 3). The morphological and MR signal features on T1, T2-weighted, dynamic enhanced, and diffusion-weighted imaging were evaluated and compared. Results: There were 10, 38, and 167 patients in group 1, 2, and 3, respectively. Patients with normal liver were older than those with fibrosis or cirrhosis (P=0.0086), and tumors in the normal liver were larger than those in the fibrotic or cirrhotic liver (P=0.0407). No statistical differences were found among groups in signals on T2-weighted images (P=0.163), signals on each phase after contrast (P=0.269, 0.893, and 0.259, respectively), enhancement patterns (P=0.753), ADC values (P=0.760), as well as the presence of capsule-like enhancement (P=0.953), mosaic pattern (P=0.572), fat content (P=0.222), iron sparing (P=1.000), hemorrhage (P=0.181), and venous invasion (P=0.175). Both signal-to-noise ratios (SNR) (χ 2=2.045, P=0.132) and lesion-to-liver contrast-to-noise ratios (CNR) (χ 2=0.438, P=0.646) were not different as well. But confusing features of iso/hypointensity on T2-weighted imaging (n=11, 6.0%) and progressive enhancement pattern (n=2, 1.1%) were exclusively found in the cirrhosis background, and hypovascular tumors with iso/hypointensity on arterial phase were only seen in the fibrosis (n=5, 11.9%) and cirrhosis groups (n=10, 5.5%). Conclusion: MR features of sHCC were similar among patients with normal, fibrotic, and cirrhotic livers. Springer Science+Business Media New York, 2015 Hepatocellular carcinoma nationallicence Cirrhosis nationallicence Fibrosis nationallicence Magnetic resonance imaging nationallicence Sheng Ruo Department of Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, 200032, Shanghai, China aut Zeng Meng Department of Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, 200032, Shanghai, China aut Ji Yuan Department of Pathology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, 200032, Shanghai, China aut Yang Li Department of Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, 200032, Shanghai, China aut Chen Cai Department of Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, 200032, Shanghai, China aut Rao Sheng Department of Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, 200032, Shanghai, China aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3062-3069 0942-8925 40:8<3062 2015 40 261 https://doi.org/10.1007/s00261-015-0536-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0536-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sheng Ruo Department of Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, 200032, Shanghai, China aut NATIONALLICENCE 700 1- Zeng Meng Department of Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, 200032, Shanghai, China aut NATIONALLICENCE 700 1- Ji Yuan Department of Pathology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, 200032, Shanghai, China aut NATIONALLICENCE 700 1- Yang Li Department of Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, 200032, Shanghai, China aut NATIONALLICENCE 700 1- Chen Cai Department of Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, 200032, Shanghai, China aut NATIONALLICENCE 700 1- Rao Sheng Department of Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, 200032, Shanghai, China aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3062-3069 0942-8925 40:8<3062 2015 40 261