Intra- and inter-examination repeatability of magnetic resonance spectroscopy, magnitude-based MRI, and complex-based MRI for estimation of hepatic proton density fat fraction in overweight and obese children and adults
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 605494711 | ||
| 003 | CHVBK | ||
| 005 | 20210128100527.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20151001xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00261-015-0542-5 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-015-0542-5 | ||
| 245 | 0 | 0 | |a Intra- and inter-examination repeatability of magnetic resonance spectroscopy, magnitude-based MRI, and complex-based MRI for estimation of hepatic proton density fat fraction in overweight and obese children and adults |h [Elektronische Daten] |c [Avishkar Tyagi, Omid Yeganeh, Yakir Levin, Jonathan Hooker, Gavin Hamilton, Tanya Wolfson, Anthony Gamst, Amir Zand, Elhamy Heba, Rohit Loomba, Jeffrey Schwimmer, Michael Middleton, Claude Sirlin] |
| 520 | 3 | |a Purpose: Determine intra- and inter-examination repeatability of magnitude-based magnetic resonance imaging (MRI-M), complex-based magnetic resonance imaging (MRI-C), and magnetic resonance spectroscopy (MRS) at 3T for estimating hepatic proton density fat fraction (PDFF), and using MRS as a reference, confirm MRI-M and MRI-C accuracy. Methods: Twenty-nine overweight and obese pediatric (n=20) and adult (n=9) subjects (23 male, 6 female) underwent three same-day 3T MR examinations. In each examination MRI-M, MRI-C, and single-voxel MRS were acquired three times. For each MRI acquisition, hepatic PDFF was estimated at the MRS voxel location. Intra- and inter-examination repeatability were assessed by computing standard deviations (SDs) and intra-class correlation coefficients (ICCs). Aggregate SD was computed for each method as the square root of the average of first repeat variances. MRI-M and MRI-C PDFF estimation accuracy was assessed using linear regression with MRS as a reference. Results: For MRI-M, MRI-C, and MRS acquisitions, respectively, mean intra-examination SDs were 0.25%, 0.42%, and 0.49%; mean intra-examination ICCs were 0.999, 0.997, and 0.995; mean inter-examination SDs were 0.42%, 0.45%, and 0.46%; and inter-examination ICCs were 0.995, 0.992, and 0.990. Aggregate SD for each method was <0.9%. Using MRS as a reference, regression slope, intercept, average bias, and R 2, respectively, for MRI-M were 0.99%, 1.73%, 1.61%, and 0.986, and for MRI-C were 0.96%, 0.43%, 0.40%, and 0.991. Conclusion: MRI-M, MRI-C, and MRS showed high intra- and inter-examination hepatic PDFF estimation repeatability in overweight and obese subjects. Longitudinal hepatic PDFF change >1.8% (twice the maximum aggregate SD) may represent real change rather than measurement imprecision. Further research is needed to assess whether examinations performed on different days or with different MR technologists affect repeatability of MRS voxel placement and MRS-based PDFF measurements. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Proton density fat fraction |2 nationallicence | |
| 690 | 7 | |a PDFF |2 nationallicence | |
| 690 | 7 | |a Hepatic steatosis |2 nationallicence | |
| 690 | 7 | |a Obesity |2 nationallicence | |
| 690 | 7 | |a Intra-examination repeatability |2 nationallicence | |
| 690 | 7 | |a Inter-examination repeatability |2 nationallicence | |
| 690 | 7 | |a Magnitude-based MRI |2 nationallicence | |
| 690 | 7 | |a Complex-based MRI |2 nationallicence | |
| 690 | 7 | |a Magnetic resonance spectroscopy |2 nationallicence | |
| 690 | 7 | |a Quantitative imaging biomarkers |2 nationallicence | |
| 700 | 1 | |a Tyagi |D Avishkar |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | |
| 700 | 1 | |a Yeganeh |D Omid |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | |
| 700 | 1 | |a Levin |D Yakir |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | |
| 700 | 1 | |a Hooker |D Jonathan |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | |
| 700 | 1 | |a Hamilton |D Gavin |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | |
| 700 | 1 | |a Wolfson |D Tanya |u Computational and Applied Statistics Laboratory (CASL), SDSC - University of California, San Diego, La Jolla, CA, USA |4 aut | |
| 700 | 1 | |a Gamst |D Anthony |u Computational and Applied Statistics Laboratory (CASL), SDSC - University of California, San Diego, La Jolla, CA, USA |4 aut | |
| 700 | 1 | |a Zand |D Amir |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | |
| 700 | 1 | |a Heba |D Elhamy |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | |
| 700 | 1 | |a Loomba |D Rohit |u Division of Gastroenterology, Department of Medicine, University of California at San Diego, La Jolla, CA, USA |4 aut | |
| 700 | 1 | |a Schwimmer |D Jeffrey |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | |
| 700 | 1 | |a Middleton |D Michael |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | |
| 700 | 1 | |a Sirlin |D Claude |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/8(2015-10-01), 3070-3077 |x 0942-8925 |q 40:8<3070 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-015-0542-5 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-015-0542-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tyagi |D Avishkar |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yeganeh |D Omid |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Levin |D Yakir |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hooker |D Jonathan |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hamilton |D Gavin |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wolfson |D Tanya |u Computational and Applied Statistics Laboratory (CASL), SDSC - University of California, San Diego, La Jolla, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gamst |D Anthony |u Computational and Applied Statistics Laboratory (CASL), SDSC - University of California, San Diego, La Jolla, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zand |D Amir |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Heba |D Elhamy |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Loomba |D Rohit |u Division of Gastroenterology, Department of Medicine, University of California at San Diego, La Jolla, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Schwimmer |D Jeffrey |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Middleton |D Michael |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sirlin |D Claude |u Liver Imaging Group, MR3T Bydder Laboratory, Department of Radiology, University of California at San Diego, 408 Dickinson Street MC 8226, 92103-8226, San Diego, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/8(2015-10-01), 3070-3077 |x 0942-8925 |q 40:8<3070 |1 2015 |2 40 |o 261 | ||